{"id":"W2153869156","doi":"10.1002/cbic.201300253","title":"Allosteric Lariat Peptide Inhibitors of Abl Kinase","year":2013,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Allosteric regulation; Kinase; ABL; Biochemistry; Enzyme; Chemistry; Allosteric enzyme; Proto-oncogene tyrosine-protein kinase Src; Peptide; Protein kinase A; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006114147,0.0001819917,0.0003235495,0.00006262914,0.00002340022,0.00001022418,0.00009456132,0.0001253916,0.001214534],"category_scores_gemma":[0.00009439079,0.0001562307,0.000129905,0.0001759421,0.00008222919,0.00007360444,0.0000822795,0.0001290364,0.0005905604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343833,"about_ca_system_score_gemma":0.0001656428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002475149,"about_ca_topic_score_gemma":0.000002277404,"domain_scores_codex":[0.9989246,0.00001078309,0.0002943896,0.0002661034,0.0002316555,0.0002725114],"domain_scores_gemma":[0.9990777,0.00003446684,0.0001093926,0.0004874827,0.000110228,0.0001807003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000526697,0.0004016956,0.01138269,0.000327705,0.0001798305,0.00004138086,0.0003679617,6.130491e-7,0.9503458,0.00003316096,0.03138627,0.005480247],"study_design_scores_gemma":[0.002579999,0.0001517539,0.01238191,0.0001449437,0.00008815878,0.00004089984,0.0001187328,0.00004869809,0.981345,0.00004182959,0.002927826,0.0001302344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808773,0.0004792677,0.000003783772,0.0005287984,0.0001164844,0.0004384147,0.000004121624,0.00006182332,0.01749001],"genre_scores_gemma":[0.9914304,0.00003118487,0.001170942,0.0002584967,0.0001714661,0.00005378691,0.00005581026,0.00003240905,0.006795522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03099924,"threshold_uncertainty_score":0.9996985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141713081552543,"score_gpt":0.2385185013521056,"score_spread":0.2271013705365802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}