{"id":"W2153876142","doi":"10.1017/s0033291715002172","title":"Polygenic interactions with environmental adversity in the aetiology of major depressive disorder","year":2015,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; King's College London; National Institute for Health and Care Research; European Commission; University of Pittsburgh; Canada Research Chairs; MQ: Transforming Mental Health; South London and Maudsley NHS Foundation Trust; GlaxoSmithKline","keywords":"Major depressive disorder; Heritability; Etiology; Depression (economics); Gene–environment interaction; Medicine; Polygenic risk score; Case-control study; Twin study; Clinical psychology; Psychiatry; Psychology; Internal medicine; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Gene; Mood","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002970281,0.00008106967,0.0001541742,0.00002748345,0.0000288078,7.25043e-7,0.0001671438,0.00009005564,0.00006360334],"category_scores_gemma":[0.0002245608,0.00004289186,0.00002788696,0.000067496,0.0002841282,0.000001433548,0.00003922794,0.000114122,0.000006219755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009354302,"about_ca_system_score_gemma":0.000004624319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005183446,"about_ca_topic_score_gemma":0.00008884069,"domain_scores_codex":[0.999184,0.0002184927,0.0001772337,0.0002002877,0.00007795169,0.0001420715],"domain_scores_gemma":[0.9995654,0.00006504802,0.00009584422,0.000210585,0.00001650066,0.000046617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004271187,0.0005451248,0.9643306,0.000003040033,0.00007352157,0.000009558485,0.0005667018,0.0001179546,0.02182402,0.0001313177,0.007539451,0.00443166],"study_design_scores_gemma":[0.001757535,0.001476456,0.9903635,0.000005260472,0.00002537158,0.00006102513,0.001652938,0.00001513169,0.0000565067,0.0004593999,0.004057399,0.00006941586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924068,0.0005954787,0.001550874,0.003103283,0.00009064144,0.0001326981,0.000006825243,0.000002503288,0.002110911],"genre_scores_gemma":[0.9983254,0.00008638491,0.000354462,0.0009485732,0.00009430642,0.00002107215,0.00006290021,0.000003469949,0.0001034494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02603302,"threshold_uncertainty_score":0.1749079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458995745330473,"score_gpt":0.3144923761169154,"score_spread":0.2899024186636107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}