{"id":"W2153876142","doi":"10.1017/s0033291715002172","title":"Polygenic interactions with environmental adversity in the aetiology of major depressive disorder","year":2015,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; Medical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; King's College London; National Institute for Health and Care Research; European Commission; University of Pittsburgh; Canada Research Chairs; MQ: Transforming Mental Health; South London and Maudsley NHS Foundation Trust; GlaxoSmithKline","keywords":"Major depressive disorder; Heritability; Etiology; Depression (economics); Gene–environment interaction; Medicine; Polygenic risk score; Case-control study; Twin study; Clinical psychology; Psychiatry; Psychology; Internal medicine; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Gene; Mood","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001315596,0.0004946282,0.00039108,0.0008143476,0.0005537157,0.0007445091,0.0004344967,0.0004669636,0.001731034],"category_scores_gemma":[0.003198229,0.0002667018,0.0006947986,0.001001926,0.0006770006,0.0002704534,0.001033007,0.0007266163,0.000131076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003966557,"about_ca_system_score_gemma":0.0004630604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004687227,"about_ca_topic_score_gemma":0.007708559,"domain_scores_codex":[0.9982501,0.0009912775,0.0001125548,0.0003107969,0.0001823065,0.0001529486],"domain_scores_gemma":[0.9974883,0.0009049891,0.0009357093,0.0002367079,0.00011504,0.0003192954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002195632,0.00004817854,0.9942231,0.00002015587,0.0004723964,0.0002211979,0.0001031067,0.0002338313,0.00121916,0.000155331,0.00006503381,0.003018858],"study_design_scores_gemma":[0.000003479674,0.00005030258,0.9991032,0.000005113527,0.00008423109,0.0001687377,0.00003256491,0.000309324,0.0000394767,0.0001547113,0.00004638583,0.000002642308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983581,0.0005197212,0.0004247843,0.0001252727,0.000006241939,0.000008300061,0.0001559595,0.000008474362,0.0003931958],"genre_scores_gemma":[0.9992679,0.0001569464,0.0003327409,0.00001922511,0.000006592878,0.000005987372,0.000143416,0.000002892152,0.00006440642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004687227,"threshold_uncertainty_score":0.009319901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458995745330473,"score_gpt":0.3144923761169154,"score_spread":0.2899024186636107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}