{"id":"W2153882592","doi":"10.2337/diabetes.55.02.06.db04-1575","title":"Impaired Gene and Protein Expression of Exocytotic Soluble <i>N</i>-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Internal medicine; Endocrinology; SNARE complex; Synaptophysin; Exocytosis; Syntaxin; Insulin; Islet; SNAP23; Biology; Munc-18; Gene expression; Western blot; Pancreatic islets; Syntaxin 3; Gene; Secretion; Medicine; Synaptic vesicle; Immunohistochemistry; Biochemistry; Peptide sequence; Vesicle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773028,0.0002874215,0.0008344795,0.000249049,0.00004934289,0.00001253556,0.00009698697,0.0001353563,0.0001690399],"category_scores_gemma":[0.0003319604,0.0002441096,0.00008860095,0.0003827824,0.0001950805,0.0001112303,0.00008113599,0.000140026,0.00001225576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008342385,"about_ca_system_score_gemma":0.00008984538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001630138,"about_ca_topic_score_gemma":0.000002458046,"domain_scores_codex":[0.9978139,0.0001518858,0.0007691003,0.0003804894,0.000431375,0.0004532596],"domain_scores_gemma":[0.9988132,0.0001006281,0.0003374716,0.0003898901,0.000222588,0.0001362647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359745,0.000665375,0.3197956,0.0008042274,0.0000236294,0.000001090124,0.00006938972,0.000007884453,0.6780622,0.00004560574,0.000143467,0.000245536],"study_design_scores_gemma":[0.003087574,0.001050963,0.1929581,0.001274083,0.0000588339,2.463482e-7,0.00004539738,0.0002558602,0.8007884,0.0001670312,0.0001259662,0.0001875307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954869,0.000630974,0.000005852187,0.00008639509,0.0000579864,0.002909801,0.00002373027,0.00005005033,0.000748286],"genre_scores_gemma":[0.9944693,0.000008030179,0.004404832,0.00005063382,0.00004448135,0.000385065,0.0001808791,0.00003496138,0.0004217713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1268375,"threshold_uncertainty_score":0.99545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660445626882261,"score_gpt":0.2371158638214351,"score_spread":0.2205114075526125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}