{"id":"W2153882592","doi":"10.2337/diabetes.55.02.06.db04-1575","title":"Impaired Gene and Protein Expression of Exocytotic Soluble <i>N</i>-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Internal medicine; Endocrinology; SNARE complex; Synaptophysin; Exocytosis; Syntaxin; Insulin; Islet; SNAP23; Biology; Munc-18; Gene expression; Western blot; Pancreatic islets; Syntaxin 3; Gene; Secretion; Medicine; Synaptic vesicle; Immunohistochemistry; Biochemistry; Peptide sequence; Vesicle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547532,0.0007583163,0.0005345512,0.0005237539,0.0001844476,0.0004767435,0.0001784329,0.0005065164,0.001459511],"category_scores_gemma":[0.0003937212,0.0002727817,0.0003272079,0.0004086087,0.0002783997,0.0001984841,0.00016244,0.0004421963,0.0002323204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002040042,"about_ca_system_score_gemma":0.00007670348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004577052,"about_ca_topic_score_gemma":0.0003007015,"domain_scores_codex":[0.9997995,0.00002257895,0.0000286614,0.00008778756,0.00003844372,0.00002298685],"domain_scores_gemma":[0.9998469,0.00002717519,0.00005297036,0.00001509174,0.00001310278,0.00004475977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006149011,0.0004015876,0.1578636,0.0001449752,0.0002381777,0.004289737,0.0004015339,0.0002662447,0.8193141,0.00009001854,0.0003145442,0.01052643],"study_design_scores_gemma":[0.0002168084,0.001426143,0.9275607,0.00001433943,0.0002364864,0.01529274,0.0003083491,0.0007894656,0.05312502,0.00009365685,0.0009099683,0.00002619191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993657,0.0001406195,0.0001839712,0.00001047537,0.000004180492,0.000003367228,0.000150592,0.00001051821,0.0001305732],"genre_scores_gemma":[0.9985177,0.0001835499,0.0003564745,0.00004811796,0.00001031924,0.00001796822,0.000477311,0.00001096798,0.0003775337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459511,"threshold_uncertainty_score":0.004882574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660445626882261,"score_gpt":0.2371158638214351,"score_spread":0.2205114075526125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}