{"id":"W2153893494","doi":"10.1038/sj.onc.1208104","title":"Retinoic acid mediates degradation of IRS-1 by the ubiquitin–proteasome pathway, via a PKC-dependant mechanism","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research and Materiel Command","keywords":"Lactacystin; Phosphorylation; Biology; Proteasome; Ubiquitin; Protein kinase C; Signal transduction; Retinoic acid; Cell biology; Cancer research; Proteasome inhibitor; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263293,0.000201063,0.0001837033,0.00002608979,0.0001162795,0.00001983147,0.0003773372,0.0002047585,0.00003475446],"category_scores_gemma":[0.0001213865,0.0001487355,0.0001129662,0.0001195526,0.0001226673,0.000006333242,0.0001218104,0.0001197913,0.00001692578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003963717,"about_ca_system_score_gemma":0.0002227876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005091386,"about_ca_topic_score_gemma":0.00002108274,"domain_scores_codex":[0.9987255,0.00007057139,0.0003087443,0.0003542571,0.0002707485,0.0002701193],"domain_scores_gemma":[0.9991479,0.00001390705,0.0002119908,0.000427395,0.0001248013,0.00007402915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000039009,0.00006517513,0.00003419129,0.00004249006,0.00003630787,0.000004316045,0.00005785288,0.00001244183,0.9954466,0.0003377801,0.0001896258,0.003734187],"study_design_scores_gemma":[0.0006380904,0.0003324953,0.000007188963,0.00002602032,0.00002838075,0.00005508374,0.00009698195,0.00001112604,0.9914867,0.002449421,0.004680567,0.0001879584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759254,0.004617834,0.0176887,0.0003230454,0.0001592655,0.0002990171,0.00005485435,0.00002167884,0.0009101949],"genre_scores_gemma":[0.9966723,0.0006281582,0.001296982,0.0002071672,0.0002045966,0.00006591543,0.0002953325,0.00003465092,0.0005949291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02074686,"threshold_uncertainty_score":0.6065259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006794478678715864,"score_gpt":0.218083491978379,"score_spread":0.2112890132996632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}