{"id":"W2153902453","doi":"10.1146/annurev.med.52.1.371","title":"Genetic Testing for Cancer Predisposition","year":2001,"lang":"en","type":"review","venue":"Annual Review of Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; Samfundet Folkhälsan; National Comprehensive Cancer Network; Susan G. Komen; Ohio State University; Breast Cancer Research Foundation; Susan G. Komen for the Cure","keywords":"Medicine; Genetic testing; Li–Fraumeni syndrome; Cancer syndrome; Familial adenomatous polyposis; Cancer; Genetic counseling; Lynch syndrome; Colorectal cancer; Disease; Medical genetics; Genetic predisposition; Breast cancer; Germline mutation; Internal medicine; Genetics; Mutation; Biology; DNA mismatch repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006729117,0.0005531978,0.00426671,0.0001964559,0.00004140147,0.000002169871,0.0002695553,0.0002881539,0.0006733719],"category_scores_gemma":[0.003095214,0.0003608573,0.0005473862,0.0009240141,0.0002513817,0.00002890478,0.00006153213,0.0003601362,0.00001308044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494446,"about_ca_system_score_gemma":0.0008473364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007455048,"about_ca_topic_score_gemma":0.000005271683,"domain_scores_codex":[0.9966276,0.000117801,0.00166203,0.0005620806,0.0006382598,0.0003922216],"domain_scores_gemma":[0.9964715,0.0007217284,0.001015129,0.0006027643,0.0009592418,0.0002296606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001058803,0.00002476967,0.00001150133,0.3648039,0.0001244141,0.000008699322,0.00001765145,6.928414e-8,0.000001837706,0.000003167512,0.02002081,0.6149726],"study_design_scores_gemma":[0.0003657249,0.00106717,0.00003024805,0.4299223,0.005329775,0.0002020383,0.000006621021,0.000001533375,8.954828e-7,0.00001213065,0.5629114,0.0001501812],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002201462,0.9911754,0.0000939098,0.0006800188,0.0007798959,0.005092395,0.0002937036,0.00004211668,0.001840424],"genre_scores_gemma":[0.000002162182,0.9915856,0.00231374,0.001423968,0.002189003,0.001436219,0.0002648275,0.0001071646,0.0006773192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6148224,"threshold_uncertainty_score":0.9998844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08089588136722027,"score_gpt":0.4228304212223608,"score_spread":0.3419345398551405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}