{"id":"W2153902453","doi":"10.1146/annurev.med.52.1.371","title":"Genetic Testing for Cancer Predisposition","year":2001,"lang":"en","type":"review","venue":"Annual Review of Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; Samfundet Folkhälsan; National Comprehensive Cancer Network; Susan G. Komen; Ohio State University; Breast Cancer Research Foundation; Susan G. Komen for the Cure","keywords":"Medicine; Genetic testing; Li–Fraumeni syndrome; Cancer syndrome; Familial adenomatous polyposis; Cancer; Genetic counseling; Lynch syndrome; Colorectal cancer; Disease; Medical genetics; Genetic predisposition; Breast cancer; Germline mutation; Internal medicine; Genetics; Mutation; Biology; DNA mismatch repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025279,0.0008173251,0.001382805,0.003198417,0.0002884312,0.000533974,0.0008483002,0.001273119,0.004779629],"category_scores_gemma":[0.002446559,0.0001581093,0.0004505838,0.002111004,0.0006019521,0.0006516683,0.0005300218,0.0009543461,0.003613305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004837684,"about_ca_system_score_gemma":0.0008878604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002367689,"about_ca_topic_score_gemma":0.003032029,"domain_scores_codex":[0.9994148,0.0001823571,0.00004752575,0.00007935298,0.0002390049,0.00003703142],"domain_scores_gemma":[0.9991986,0.0004966918,0.00007627148,0.00003428651,0.0001495993,0.00004462793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004652761,0.00005832448,0.003031024,0.004205915,0.0001128132,0.00253426,0.00007776007,0.0001814119,0.001141574,0.002246066,0.06581739,0.9205469],"study_design_scores_gemma":[0.00005158055,0.00009320065,0.008776378,0.008294887,0.0002255257,0.03711528,0.0001725127,0.0001425814,0.001189878,0.004735242,0.9391624,0.00004047345],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006025326,0.9875958,0.0006106324,0.00132662,0.0004158012,0.00001569824,0.0000589745,0.00003700984,0.009336925],"genre_scores_gemma":[0.005165224,0.9904808,0.000762535,0.0009060584,0.0003721612,0.00001386692,0.0001152422,0.000004593395,0.002179494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004779629,"threshold_uncertainty_score":0.01598948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08089588136722027,"score_gpt":0.4228304212223608,"score_spread":0.3419345398551405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}