{"id":"W2153904259","doi":"10.1073/pnas.0601072103","title":"Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Pressure overload; Contractility; Endocrinology; Phospholamban; Muscle hypertrophy; Cardiac function curve; Triiodothyronine; SERCA; Heart failure; Medicine; Biology; Thyroid; ATPase; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141294,0.0004493529,0.0004733602,0.0002253845,0.0001771533,0.0003035415,0.0003028307,0.0003225924,0.001014012],"category_scores_gemma":[0.0001606041,0.0001181882,0.0003309585,0.0001378302,0.0002827373,0.0001992452,0.0002635128,0.0006477121,0.0002568619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177731,"about_ca_system_score_gemma":0.0003011114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004727861,"about_ca_topic_score_gemma":0.00124097,"domain_scores_codex":[0.9998748,0.00001738718,0.00001365604,0.00002857603,0.00002185301,0.00004361676],"domain_scores_gemma":[0.9998765,0.00001402642,0.00003124977,0.00001619396,0.00001580621,0.00004624181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003503815,0.0001036036,0.0001401485,0.00003894892,0.000007088899,0.00002134552,0.00001373752,0.00004049124,0.9976385,0.00004423245,0.00005629619,0.001545259],"study_design_scores_gemma":[0.0002054503,0.003935296,0.01173462,0.00002059587,0.00006464448,0.0001579927,0.00004908367,0.0008767928,0.9793392,0.00007529181,0.003529074,0.0000119415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913504,0.002553227,0.003809876,0.0001786228,0.0001056521,0.0001146699,0.0003737611,0.0001965279,0.001317198],"genre_scores_gemma":[0.9915804,0.001736172,0.003240047,0.0001477605,0.00004434748,0.0001385018,0.0005829386,0.00004274799,0.00248708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014012,"threshold_uncertainty_score":0.00339222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193238582296555,"score_gpt":0.284007836974809,"score_spread":0.2646839787451535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}