{"id":"W2153907656","doi":"10.1016/s2213-2600(13)70182-6","title":"Assessment of clinical response to ivacaftor with lung clearance index in cystic fibrosis patients with a G551D- CFTR mutation and preserved spirometry: a randomised controlled trial","year":2013,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Imperial College London; National Institute for Health and Care Research; Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Spirometry; Placebo; Crossover study; Internal medicine; Gastroenterology; Cystic fibrosis transmembrane conductance regulator; Pathology; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00520938,0.0002900854,0.002043711,0.0003668189,0.00006938034,0.00002439051,0.0002634861,0.0001049115,0.0001637189],"category_scores_gemma":[0.01104007,0.0001415651,0.00007053732,0.0008194234,0.0005717215,0.000176685,0.00008034994,0.0005449203,0.000003747557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001165147,"about_ca_system_score_gemma":0.0003827298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000136523,"about_ca_topic_score_gemma":0.00003237243,"domain_scores_codex":[0.994877,0.00157097,0.001237994,0.0004987997,0.001331594,0.0004836658],"domain_scores_gemma":[0.9929342,0.004927016,0.000510662,0.0007504022,0.000517485,0.0003602169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7400465,0.0002789671,0.2558391,0.0002021235,0.0001483101,0.00002350583,0.0001002561,0.00006005299,0.001966072,0.000007203074,0.000490831,0.0008370315],"study_design_scores_gemma":[0.4408496,0.009316072,0.5477698,0.0007661934,0.000093026,0.00000187851,0.00007090035,0.0007374811,0.00003045707,0.00001034575,0.0002642339,0.00009003816],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984964,0.0004379716,0.000720713,0.001997634,0.00006238168,0.01155526,0.00001107697,0.00003400825,0.0002170057],"genre_scores_gemma":[0.9950528,0.00001712201,0.001811798,0.0006992892,0.0004120167,0.001892675,0.000008711577,0.00003772859,0.00006782827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2991969,"threshold_uncertainty_score":0.9972904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484491053575212,"score_gpt":0.3829189364481914,"score_spread":0.3480740259124393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}