{"id":"W2153959970","doi":"10.1126/scisignal.2001796","title":"Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling","year":2011,"lang":"en","type":"article","venue":"Science Signaling","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; European Commission; Wellcome Trust; Ludwig Institute for Cancer Research","keywords":"Phosphorylation; Context (archaeology); Biology; Cell biology; Mitosis; Selection (genetic algorithm); Signal transduction; Computational biology; Computer science; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004876429,0.000107816,0.0001173277,0.00004277817,0.0003113885,0.00002779187,0.0001403881,0.00005225666,0.00001101376],"category_scores_gemma":[0.00009173023,0.0000781499,0.00004720197,0.0001544884,0.0003434618,0.00001691506,0.000056484,0.00005600302,2.62974e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331387,"about_ca_system_score_gemma":0.0001311878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920449,"about_ca_topic_score_gemma":0.0001503444,"domain_scores_codex":[0.9991432,0.00003730496,0.0001497963,0.0003168853,0.0001677491,0.0001851078],"domain_scores_gemma":[0.9993218,0.00004916495,0.0001392804,0.0001216714,0.0003242533,0.00004381214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002833204,0.00003447999,0.002406957,0.00001142572,0.00004094733,1.467112e-7,0.001646358,0.0001870234,0.9928474,0.00009498461,0.000002950146,0.002444015],"study_design_scores_gemma":[0.000400958,0.0007511044,0.002459191,0.00003491113,0.00005084022,0.000003824993,0.0007910272,0.004831352,0.9903688,0.0001949022,0.000005154438,0.0001078893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9127752,0.00007741537,0.08658814,0.00003010821,0.00004983463,0.0003993656,0.00001854923,0.000004322519,0.00005701718],"genre_scores_gemma":[0.9977785,0.00001019057,0.002007608,0.0001118425,0.00003606031,0.00001815028,0.000004955163,0.000009040594,0.00002363537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08500327,"threshold_uncertainty_score":0.3186861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190008958616659,"score_gpt":0.2283105211492889,"score_spread":0.2164104315631223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}