{"id":"W2153968413","doi":"10.1038/ng.2232","title":"Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":413,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund; Biogen; Canada Research Chairs; Wellcome Trust","keywords":"Genome-wide association study; Biology; Genetic architecture; Single-nucleotide polymorphism; Rheumatoid arthritis; Genetics; Quantitative trait locus; Immunology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02256564,0.0009365228,0.001960089,0.002910304,0.001567656,0.00224241,0.003089661,0.001664411,0.003568374],"category_scores_gemma":[0.07797477,0.001503127,0.00259448,0.002048102,0.001826245,0.002241072,0.002034595,0.003859292,0.0003983196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001549167,"about_ca_system_score_gemma":0.001843149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01483036,"about_ca_topic_score_gemma":0.01789027,"domain_scores_codex":[0.9908946,0.007021229,0.0003309896,0.0009436177,0.0004845276,0.0003250871],"domain_scores_gemma":[0.8769673,0.1157793,0.002347097,0.003196564,0.001030308,0.0006795273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001796477,0.0003805179,0.06951478,0.0004007659,0.003655079,0.0007042538,0.001035581,0.6255928,0.003610116,0.1758978,0.004015962,0.1133959],"study_design_scores_gemma":[0.0002230639,0.00006936336,0.01292503,0.00005987593,0.0003726089,0.0001510278,0.00007485355,0.7889271,0.0003973477,0.1959572,0.0007853361,0.00005719561],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2783116,0.002420395,0.7134928,0.002095202,0.00007203069,0.00009868723,0.001108134,0.000487673,0.001913518],"genre_scores_gemma":[0.8982297,0.001043837,0.09578829,0.0004463366,0.0002189128,0.0001477901,0.001547395,0.0001569854,0.002420926],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02256564,"threshold_uncertainty_score":0.11934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219402205233201,"score_gpt":0.3011409096873932,"score_spread":0.2889468876350612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}