{"id":"W2154010882","doi":"10.1016/j.biomaterials.2009.11.003","title":"The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine","year":2009,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Ministry of Education – Kingdom of Saudi Arabi; National Institute for Health and Care Research","keywords":"Polyethylenimine; STAT3; Apoptosis; Viability assay; STAT protein; Downregulation and upregulation; Small interfering RNA; Gene silencing; Cytotoxicity; In vivo; Molecular biology; Chemistry; Materials science; Cancer research; Transfection; Cell culture; Pharmacology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132556,0.0001468068,0.0001938145,0.00006159662,0.00006430111,0.00003800257,0.0001817152,0.00008735622,0.000007094809],"category_scores_gemma":[0.00003707824,0.00009920359,0.00006787697,0.0001163834,0.00005428478,0.00001093006,0.0000348113,0.00001289768,0.000004434223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001495712,"about_ca_system_score_gemma":0.00006247024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464331,"about_ca_topic_score_gemma":0.00007957487,"domain_scores_codex":[0.9990468,0.00007067498,0.0003157843,0.0002332383,0.0001140918,0.0002193883],"domain_scores_gemma":[0.9994949,0.00001076103,0.0001389333,0.0002630917,0.0000554359,0.00003693902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004421056,0.00004542221,0.000657032,0.000005537131,0.00004895073,0.000004500971,0.00006404037,0.00000503135,0.9965487,0.00001382245,0.0001716578,0.001993168],"study_design_scores_gemma":[0.0005436264,0.0005723474,0.009440543,0.00004995014,0.00001992903,0.000009735804,0.0001321212,0.000002164443,0.9884307,0.00002446961,0.0006374436,0.0001369994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988412,0.0003641248,0.00003558034,0.0001247838,0.0003440208,0.0001742422,0.00001931218,0.0000104937,0.00008626693],"genre_scores_gemma":[0.9992856,0.0001351093,0.0002144902,0.0000797155,0.0001580869,0.0000153803,0.00005352156,0.00001027212,0.00004787104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008783511,"threshold_uncertainty_score":0.4045405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060432975425223,"score_gpt":0.2372837971531871,"score_spread":0.2266794673989349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}