{"id":"W2154010882","doi":"10.1016/j.biomaterials.2009.11.003","title":"The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine","year":2009,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Ministry of Education – Kingdom of Saudi Arabi; National Institute for Health and Care Research","keywords":"Polyethylenimine; STAT3; Apoptosis; Viability assay; STAT protein; Downregulation and upregulation; Small interfering RNA; Gene silencing; Cytotoxicity; In vivo; Molecular biology; Chemistry; Materials science; Cancer research; Transfection; Cell culture; Pharmacology; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510859,0.0002133563,0.0001052106,0.0001529233,0.0001314737,0.0001584358,0.0001215231,0.0002422626,0.0006764489],"category_scores_gemma":[0.00007681408,0.0001194689,0.0001919487,0.00009515006,0.0001421795,0.0001684833,0.0001049748,0.0003414233,0.0001646203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002308912,"about_ca_system_score_gemma":0.0001822081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006501256,"about_ca_topic_score_gemma":0.000832009,"domain_scores_codex":[0.9999158,0.0000135299,0.00000884449,0.00001251182,0.0000242948,0.00002493035],"domain_scores_gemma":[0.9999326,0.00001726996,0.00001985072,0.000008808041,0.000009901712,0.00001152505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005472077,0.000007644215,0.00003478386,0.00001460597,0.000001399243,0.00001648908,0.000007926283,0.00002442352,0.9993618,0.00006089832,0.00000973799,0.0004056306],"study_design_scores_gemma":[0.000003904732,0.00005803258,0.0003746036,8.697269e-7,0.00000232461,0.00002977928,0.000003771628,0.0001898939,0.9990784,0.000008973816,0.0002487957,5.964864e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942281,0.0009186012,0.003164338,0.0000812819,0.0000208934,0.00002671576,0.0001399716,0.00005490517,0.001365276],"genre_scores_gemma":[0.9953306,0.0003627434,0.001745768,0.00003016896,0.000002774185,0.00002882347,0.0001144953,0.0000109652,0.002373794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006764489,"threshold_uncertainty_score":0.00226295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060432975425223,"score_gpt":0.2372837971531871,"score_spread":0.2266794673989349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}