{"id":"W2154040159","doi":"10.1158/1535-7163.mct-08-0021","title":"Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Oak Ridge Institute for Science and Education","keywords":"microRNA; Cancer research; Cancer cell; Doxorubicin; Breast cancer chemotherapy; Cancer; Transfection; Biology; Epigenetics; Breast cancer; MCF-7; Drug resistance; Gene silencing; Multiple drug resistance; Cell culture; Gene; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300362,0.0002273809,0.0002592267,0.00007292305,0.00004979413,0.000005413262,0.0004421392,0.0001129017,0.00003222573],"category_scores_gemma":[0.000002914645,0.0001966225,0.000164365,0.000393067,0.0001845584,0.000004065671,0.0001175062,0.0001000678,0.000001174725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215975,"about_ca_system_score_gemma":0.0003089249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002987227,"about_ca_topic_score_gemma":0.000671403,"domain_scores_codex":[0.9985027,0.0001139881,0.0004240088,0.0003663647,0.0003012051,0.0002916828],"domain_scores_gemma":[0.9988173,0.000007715645,0.0002401255,0.0006850901,0.0001884323,0.0000612994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002278254,0.0001285753,0.007594722,0.00009273171,0.0001457965,0.000001671551,0.0004284585,0.001549562,0.9888824,0.00001924453,0.0002769557,0.0006520728],"study_design_scores_gemma":[0.0007344747,0.00002371277,0.02853227,0.0001468149,0.00005488636,0.000002462006,0.00004079712,0.00002769167,0.9640594,0.0000392812,0.006134213,0.0002040212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893808,0.008169075,0.0003672591,0.001147706,0.0001625521,0.0005451008,0.0001541827,0.000005640661,0.00006769203],"genre_scores_gemma":[0.9962324,0.0009512859,0.000320874,0.001950221,0.00005162844,0.00007387828,0.000008983857,0.00004960885,0.0003611382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02482301,"threshold_uncertainty_score":0.8018032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127625030576074,"score_gpt":0.251522607907698,"score_spread":0.2387601048500906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}