{"id":"W2154057556","doi":"10.1016/j.str.2013.03.001","title":"Molecular Organization and ATP-Induced Conformational Changes of ABCA4, the Photoreceptor-Specific ABC Transporter","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canada Research Chairs","keywords":"ATP-binding cassette transporter; Subfamily; Flippase; ABCA4; Biochemistry; Biology; Biophysics; Transmembrane domain; Cytoplasm; Transmembrane protein; Nucleotide; Walker motifs; Chemistry; Cell biology; ATPase; Transporter; Membrane; ATP hydrolysis; Phosphatidylserine; Receptor; Phospholipid; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009524383,0.0001333075,0.00009179103,0.0001321063,0.0003005146,0.000235495,0.0002724168,0.0002135629,0.002260017],"category_scores_gemma":[0.0002254,0.0001481108,0.0001562582,0.0001244303,0.0003102583,0.0004244484,0.0001265967,0.0005721113,0.0002617108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004416706,"about_ca_system_score_gemma":0.0001635703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007488332,"about_ca_topic_score_gemma":0.0007147119,"domain_scores_codex":[0.999956,0.00001086257,0.000001934575,0.000009479755,0.000007995896,0.00001373954],"domain_scores_gemma":[0.9999228,0.00001788619,0.00002620842,0.000007722754,0.00001182352,0.00001356558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005456543,0.00008975452,0.001645194,0.00007822573,0.0000298281,0.0004472045,0.0001037631,0.001818646,0.9870043,0.0033542,0.0004704523,0.004412581],"study_design_scores_gemma":[0.0001302381,0.0006532542,0.0423464,0.00002174513,0.00007962181,0.00118497,0.0004574909,0.02456144,0.9182903,0.002827492,0.009391089,0.00005595628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964071,0.000670808,0.001084908,0.0002695162,0.00001962375,0.000004523851,0.00008596464,0.00001804921,0.001439658],"genre_scores_gemma":[0.9980844,0.0002421687,0.0004335269,0.00005909377,0.000007922396,0.000005610415,0.0002199651,0.000006962639,0.0009402903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260017,"threshold_uncertainty_score":0.007560551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004971582686508048,"score_gpt":0.1896564968154851,"score_spread":0.1846849141289771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}