{"id":"W2154057556","doi":"10.1016/j.str.2013.03.001","title":"Molecular Organization and ATP-Induced Conformational Changes of ABCA4, the Photoreceptor-Specific ABC Transporter","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canada Research Chairs","keywords":"ATP-binding cassette transporter; Subfamily; Flippase; ABCA4; Biochemistry; Biology; Biophysics; Transmembrane domain; Cytoplasm; Transmembrane protein; Nucleotide; Walker motifs; Chemistry; Cell biology; ATPase; Transporter; Membrane; ATP hydrolysis; Phosphatidylserine; Receptor; Phospholipid; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002988389,0.0001087872,0.0001573712,0.00004022755,0.0000569979,0.00001222523,0.00006029922,0.00009580966,0.001592782],"category_scores_gemma":[0.000003082709,0.00006464164,0.00002751243,0.0001424022,0.00006235011,0.00005790844,0.000003984701,0.0001068311,0.000004477542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009692528,"about_ca_system_score_gemma":0.00002586642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000701268,"about_ca_topic_score_gemma":0.000006708603,"domain_scores_codex":[0.9994035,0.000007080874,0.0001503573,0.0001128765,0.0002144641,0.0001117297],"domain_scores_gemma":[0.9995659,0.000007268699,0.00006410907,0.0001464313,0.0001637137,0.00005257287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002537614,0.00001018515,0.001535068,0.0001044238,0.00004738835,0.00000376088,0.002819353,0.000002222619,0.989404,0.003032565,0.0002266755,0.002789003],"study_design_scores_gemma":[0.00115438,0.00009576995,0.1564344,0.00006222795,0.00008087794,0.00004241839,0.0009086758,0.00003225465,0.83294,0.0008932579,0.007188044,0.0001677323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971324,0.0001899895,0.000379009,0.00133194,0.0001561471,0.0004109965,0.00002877047,0.00002307464,0.0003476409],"genre_scores_gemma":[0.998899,0.00005522916,0.0003382412,0.0003642684,0.00007681981,0.000005782364,0.0001642099,0.00001626345,0.00008018421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156464,"threshold_uncertainty_score":0.9993199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004971582686508048,"score_gpt":0.1896564968154851,"score_spread":0.1846849141289771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}