{"id":"W2154058662","doi":"10.1152/ajpcell.00267.2007","title":"Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":351,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"AMPK; Mitochondrial biogenesis; Reactive oxygen species; Cell biology; Coactivator; Transcription factor; Downregulation and upregulation; Mitochondrial ROS; Chemistry; Peroxisome proliferator-activated receptor; TFAM; NRF1; Protein kinase A; Biology; Phosphorylation; Mitochondrion; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187035,0.0002988891,0.0003334491,0.0002300265,0.0002267766,0.0003470496,0.0002044574,0.000321756,0.001126274],"category_scores_gemma":[0.0001212536,0.0002475294,0.0003695093,0.0001812473,0.0002906459,0.0003138806,0.0002610469,0.0005121803,0.0004040081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076709,"about_ca_system_score_gemma":0.0002195662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005712414,"about_ca_topic_score_gemma":0.0009176697,"domain_scores_codex":[0.9998385,0.00003622535,0.00001828281,0.00004470164,0.0000348989,0.00002742011],"domain_scores_gemma":[0.9999216,0.00001338333,0.00002180492,0.000007931244,0.00001528379,0.00002009865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006253929,0.00008076504,0.0005411058,0.0001642633,0.00001719538,0.0001240443,0.00004376812,0.000149877,0.9951302,0.0001351222,0.00008238234,0.002905862],"study_design_scores_gemma":[0.0002562912,0.001170191,0.06998468,0.00008500256,0.000104992,0.0005984908,0.0002345958,0.003122166,0.9112195,0.0007372319,0.01245872,0.00002810357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394554,0.04649149,0.0072674,0.0009771449,0.0003488533,0.00009591252,0.0005719374,0.0001001008,0.004691837],"genre_scores_gemma":[0.9836335,0.008170545,0.002868823,0.0002518344,0.00009434012,0.00007768071,0.0004877957,0.00001626836,0.004399219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126274,"threshold_uncertainty_score":0.003767729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105453463701713,"score_gpt":0.2785597491369126,"score_spread":0.2575052144998954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}