{"id":"W2154082780","doi":"10.1186/s13071-015-0716-6","title":"Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs","year":2015,"lang":"en","type":"article","venue":"Parasites & Vectors","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Doublesex; Sterile insect technique; RNA interference; Population; Aedes aegypti; Mating; Biotechnology; Gene knockdown; Vector (molecular biology); Genetics; Gene; Larva; Ecology; PEST analysis; Botany; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736334,0.0001311281,0.0001310013,0.00003262432,0.00004079614,0.00002323996,0.0001707096,0.00008593262,0.000005430247],"category_scores_gemma":[0.00006178742,0.00009915238,0.00005694498,0.0001194008,0.0000143869,0.000005030288,0.00005877408,0.00006237926,0.000003842977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001383272,"about_ca_system_score_gemma":0.00002620897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004049808,"about_ca_topic_score_gemma":0.00002380589,"domain_scores_codex":[0.9992146,0.00002191467,0.0001778834,0.000230725,0.0001620651,0.0001928094],"domain_scores_gemma":[0.9995419,0.00001332135,0.00005133329,0.000218529,0.00004054553,0.000134359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008357396,0.00002479865,0.01479947,0.00001628839,0.00002418774,1.332307e-7,0.0006685092,0.01420146,0.9635754,0.0000116186,0.00595881,0.0006357298],"study_design_scores_gemma":[0.0005787419,0.00009339938,0.0133571,0.00002268904,0.00002895292,0.000005166862,0.0002791914,0.0007377035,0.981337,0.00001980743,0.003370083,0.0001701783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860508,0.0006325982,0.0122824,0.00005636446,0.0001622294,0.0001996782,0.000005554819,0.00001528076,0.0005950739],"genre_scores_gemma":[0.9981853,0.00001605043,0.001129144,0.00002718897,0.0002074065,0.00001136815,0.0001048573,0.00001812146,0.0003005095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01776156,"threshold_uncertainty_score":0.4043317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223803550170427,"score_gpt":0.3150111125513433,"score_spread":0.2927730770496391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}