{"id":"W2154082780","doi":"10.1186/s13071-015-0716-6","title":"Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs","year":2015,"lang":"en","type":"article","venue":"Parasites & Vectors","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Doublesex; Sterile insect technique; RNA interference; Population; Aedes aegypti; Mating; Biotechnology; Gene knockdown; Vector (molecular biology); Genetics; Gene; Larva; Ecology; PEST analysis; Botany; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364339,0.0005873769,0.0003639332,0.0003540456,0.000293609,0.000572846,0.0006236358,0.0004299784,0.002037741],"category_scores_gemma":[0.0001385552,0.0002622483,0.0004546086,0.0001299136,0.0004499528,0.0004699324,0.0004421987,0.0013992,0.0006747883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437524,"about_ca_system_score_gemma":0.0001797311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003795716,"about_ca_topic_score_gemma":0.0007626245,"domain_scores_codex":[0.9998436,0.00001596017,0.0000108376,0.00005398279,0.00005676783,0.00001879739],"domain_scores_gemma":[0.9998982,0.00001635734,0.00003387461,0.00001208518,0.00001597692,0.00002356875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005026372,0.00002926167,0.0001103286,0.00008798763,0.00001099342,0.00004210118,0.00001904376,0.00006530098,0.9906974,0.0006809819,0.0003479952,0.007858353],"study_design_scores_gemma":[0.00005901672,0.0006062835,0.002288304,0.00002766836,0.00008519799,0.000719696,0.00004756802,0.003565378,0.9449465,0.0004488664,0.04717432,0.00003115475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5346692,0.03846803,0.3865555,0.003063343,0.001749538,0.0009097414,0.002067653,0.005928828,0.02658819],"genre_scores_gemma":[0.773242,0.02436196,0.1587189,0.001580169,0.0003213415,0.0006918091,0.002285529,0.0005978128,0.03820046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002037741,"threshold_uncertainty_score":0.006816924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223803550170427,"score_gpt":0.3150111125513433,"score_spread":0.2927730770496391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}