{"id":"W2154086425","doi":"10.1007/s10637-009-9251-7","title":"Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants","year":2009,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Antiandrogens; LNCaP; Chalcone; Antiandrogen; Prostate cancer; Androgen receptor; Pharmacology; Antagonist; Cancer research; Chemistry; Biology; Internal medicine; Endocrinology; Medicine; Cancer; Receptor; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812926,0.0003741027,0.0002619235,0.0003698527,0.0002024751,0.0002299739,0.0003161872,0.0001801817,0.001892034],"category_scores_gemma":[0.0001764993,0.00009433389,0.0002459607,0.0004012398,0.0001766183,0.0001817978,0.0001292778,0.0002613771,0.0004236696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003734847,"about_ca_system_score_gemma":0.0003695172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001670653,"about_ca_topic_score_gemma":0.002705644,"domain_scores_codex":[0.9999075,0.0000216911,0.000010655,0.0000121067,0.00002304208,0.00002506703],"domain_scores_gemma":[0.9999009,0.00001916365,0.00001891585,0.00001269625,0.00002219861,0.00002611254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004436875,0.00009283633,0.0001214431,0.00009072868,0.000008069219,0.0001403672,0.00003079799,0.000638304,0.9941135,0.0001822936,0.0001243381,0.004013625],"study_design_scores_gemma":[0.00004945181,0.0007322094,0.0007739501,0.000005837162,0.00001912151,0.0000863216,0.00001953286,0.0003162902,0.994499,0.00003962469,0.003451064,0.000007620656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754151,0.005989484,0.009299512,0.0001453385,0.00008194335,0.0003026859,0.002017876,0.0001623929,0.006585687],"genre_scores_gemma":[0.9873363,0.002101631,0.003653548,0.00005266445,0.00001535279,0.00005036864,0.002172372,0.00003253648,0.004585193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892034,"threshold_uncertainty_score":0.006329477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02241470249151526,"score_gpt":0.2939460139984815,"score_spread":0.2715313115069662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}