{"id":"W2154094145","doi":"10.2147/tcrm.s1709","title":"Combating HIV resistance &amp;ndash; focus on darunavir","year":2008,"lang":"en","type":"article","venue":"Therapeutics and Clinical Risk Management","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Darunavir; Medicine; Human immunodeficiency virus (HIV); Focus (optics); Virology; Pharmacology; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000519646,0.0002120928,0.0003716674,0.00006538306,0.0002686784,0.00001856906,0.00009197203,0.00007852521,0.00005683292],"category_scores_gemma":[0.00002203183,0.0001594145,0.0001302438,0.0001313519,0.0001644207,0.00002460463,0.00008147716,0.0002760015,0.0002310724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004811542,"about_ca_system_score_gemma":0.0000221744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003437197,"about_ca_topic_score_gemma":0.00002134053,"domain_scores_codex":[0.9983543,0.0001002895,0.0005231001,0.0004037494,0.0003421949,0.000276385],"domain_scores_gemma":[0.9989794,0.0002620704,0.0001490511,0.0004172958,0.00003770996,0.0001544025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001887094,0.003617747,0.5430915,0.0001385236,0.003505591,0.0004214514,0.001262446,0.000004151719,0.000005526478,0.02783572,0.01542356,0.4028067],"study_design_scores_gemma":[0.006502631,0.0004538142,0.2461266,0.0002343803,0.0009195161,0.0000071359,0.000174226,0.0001299623,0.00003491921,0.006738205,0.7383226,0.0003560839],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8627304,0.001905347,0.001494025,0.01683346,0.0002592989,0.0012062,0.00001983567,0.0002052811,0.1153461],"genre_scores_gemma":[0.8721315,0.02992111,0.01467923,0.002241323,0.0001335739,0.00003290669,0.00003344775,0.00004096361,0.08078593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.722899,"threshold_uncertainty_score":0.6500733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06666891908404485,"score_gpt":0.3536715826461732,"score_spread":0.2870026635621283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}