{"id":"W2154101400","doi":"10.1158/0008-5472.can-03-2270","title":"Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in <b> <i>p53</i> </b>+/− Mutant Mice","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Prevent Cancer Foundation","keywords":"Mammary gland; Biology; Mammary tumor; Carcinogenesis; BRCA2 Protein; Cancer research; Involution (esoterism); Adenocarcinoma; Tumor suppressor gene; Epithelium; Genetically modified mouse; Breast cancer; Internal medicine; Cancer; Transgene; Mutation; Germline mutation; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001236505,0.0003006568,0.0003995137,0.0007674306,0.0002380023,0.0000905578,0.0005109775,0.0002519637,0.00005442632],"category_scores_gemma":[0.0002143423,0.0002460334,0.0001043496,0.001230629,0.0001746957,0.0004511054,0.0003590669,0.001099026,0.0001210223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003131271,"about_ca_system_score_gemma":0.003222749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176836,"about_ca_topic_score_gemma":0.0008308496,"domain_scores_codex":[0.9959518,0.0001687554,0.0006521347,0.0007157688,0.001353758,0.001157793],"domain_scores_gemma":[0.9982899,0.00007821395,0.0001064716,0.0007026412,0.0004770411,0.000345676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005536973,0.0004119852,0.001399195,0.000986998,0.00004830429,0.001446221,0.004367573,0.0001288735,0.9681202,0.0006595646,0.0002868262,0.0215906],"study_design_scores_gemma":[0.003547457,0.0003783231,0.0129461,0.0009290978,0.00001901232,0.0003962938,0.0004131203,0.0001491867,0.9786037,0.0006038931,0.001660082,0.0003536943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804208,0.006011761,0.00300275,0.007251611,0.0002389086,0.001933652,0.00003392923,0.0001547207,0.0009518961],"genre_scores_gemma":[0.994446,0.001088159,0.002604162,0.0004924063,0.0001569355,0.0006739068,0.00004853073,0.0000659254,0.0004239527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0212369,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04022672030561803,"score_gpt":0.3208763635096949,"score_spread":0.2806496432040769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}