{"id":"W2154101400","doi":"10.1158/0008-5472.can-03-2270","title":"Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in <b> <i>p53</i> </b>+/− Mutant Mice","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Prevent Cancer Foundation","keywords":"Mammary gland; Biology; Mammary tumor; Carcinogenesis; BRCA2 Protein; Cancer research; Involution (esoterism); Adenocarcinoma; Tumor suppressor gene; Epithelium; Genetically modified mouse; Breast cancer; Internal medicine; Cancer; Transgene; Mutation; Germline mutation; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217971,0.0006132196,0.0003594456,0.0007984815,0.0002330896,0.0004402509,0.0003216699,0.0005208677,0.002214176],"category_scores_gemma":[0.000195887,0.000405253,0.0002971786,0.0001903429,0.0003820187,0.0002477196,0.0002604736,0.0008602143,0.0007428851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003023003,"about_ca_system_score_gemma":0.0002578921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088823,"about_ca_topic_score_gemma":0.001662697,"domain_scores_codex":[0.9997451,0.00004407849,0.00002547158,0.00006241078,0.00006636139,0.00005655075],"domain_scores_gemma":[0.9994824,0.00007284221,0.0001657471,0.00004833835,0.00002255591,0.0002081964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009855595,0.00003097789,0.0002515248,0.00001177404,0.000005290925,0.00009844199,0.000009853972,0.0000297818,0.9989837,0.00006163422,0.00003493124,0.000383589],"study_design_scores_gemma":[0.0000775694,0.0006028424,0.01288975,0.00001638905,0.00003496587,0.002185213,0.00005688619,0.0008828255,0.9803141,0.0001230148,0.002806242,0.00001022655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949249,0.0007848761,0.001718882,0.0001390741,0.00002003426,0.00002482214,0.0007940898,0.0002006557,0.001392609],"genre_scores_gemma":[0.9879507,0.001010123,0.002361567,0.0001132432,0.00001713192,0.00005671288,0.001222112,0.0001686829,0.007099655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002214176,"threshold_uncertainty_score":0.007407129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04022672030561803,"score_gpt":0.3208763635096949,"score_spread":0.2806496432040769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}