{"id":"W2154101477","doi":"10.1124/mol.105.015768","title":"A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Nucleoside transporter; Cladribine; Nucleoside; Nucleoside analogue; Clofarabine; Biochemistry; Biology; Fludarabine; Cytotoxicity; Chemistry; Transporter; Cytarabine; Leukemia; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170834,0.0002713049,0.0003778297,0.0001785069,0.0001633301,0.0005069316,0.0002246632,0.0003050367,0.0003958339],"category_scores_gemma":[0.0003352552,0.0001278568,0.0002760544,0.0001784834,0.0002116217,0.000414751,0.00009911889,0.0003508976,0.0001543722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005315279,"about_ca_system_score_gemma":0.0002845418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001787962,"about_ca_topic_score_gemma":0.00117176,"domain_scores_codex":[0.9998647,0.00003391696,0.00001932073,0.00002560557,0.00002950553,0.00002692382],"domain_scores_gemma":[0.9997466,0.0001090309,0.00003677384,0.00004141935,0.00003913305,0.00002705184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001742886,0.00001078053,0.0001063196,0.00001601167,0.000004038419,0.00001864424,0.00001385013,0.0001397866,0.9986749,0.0001523451,0.000008794261,0.0006803748],"study_design_scores_gemma":[0.000005769096,0.0001605593,0.001052118,0.000002069656,0.00001674575,0.0001072431,0.00001250276,0.001087944,0.9969481,0.00002268019,0.0005805366,0.00000375375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936249,0.0009001899,0.004087634,0.00005814041,0.000008447493,0.00001259749,0.0002375288,0.00005148441,0.00101898],"genre_scores_gemma":[0.9954858,0.0006051435,0.002345935,0.00001659514,0.000002862181,0.00001274598,0.0006541218,0.00002738701,0.0008494924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787962,"threshold_uncertainty_score":0.00385648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412350303507927,"score_gpt":0.2940807132762104,"score_spread":0.2799572102411311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}