{"id":"W2154101477","doi":"10.1124/mol.105.015768","title":"A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Nucleoside transporter; Cladribine; Nucleoside; Nucleoside analogue; Clofarabine; Biochemistry; Biology; Fludarabine; Cytotoxicity; Chemistry; Transporter; Cytarabine; Leukemia; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002645114,0.0001908745,0.0004117103,0.00007431506,0.00003471129,0.00000377879,0.0001946139,0.0001753146,0.000005590713],"category_scores_gemma":[0.000008518859,0.0001621766,0.00006112605,0.0001267345,0.0001131091,0.000009073409,0.000064261,0.0001842204,6.778202e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001466228,"about_ca_system_score_gemma":0.00003884437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008906764,"about_ca_topic_score_gemma":0.00008075065,"domain_scores_codex":[0.9984986,0.0001280405,0.0006083213,0.0004041258,0.0001261372,0.0002347285],"domain_scores_gemma":[0.9995137,0.00001052864,0.0001818323,0.000191553,0.00004633368,0.00005607149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162442,0.0003652446,0.05545429,0.0001196839,0.00002191077,0.000002975023,0.0002224063,0.01332477,0.9300386,0.0000419199,0.0001933809,0.00005239848],"study_design_scores_gemma":[0.002075907,0.0001940368,0.007622364,0.00005680314,0.00004050934,0.000006114501,0.00004379566,0.01825394,0.9714413,0.00004356957,0.00006358151,0.0001581316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909055,0.007829959,0.00026983,0.0002525305,0.00004378504,0.0006362605,0.00002353,0.000004791105,0.00003387842],"genre_scores_gemma":[0.9996133,0.0001054243,0.00007307181,0.00007380396,0.00001986619,0.00004787256,0.0000294817,0.00002135323,0.00001577121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04783192,"threshold_uncertainty_score":0.6613371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412350303507927,"score_gpt":0.2940807132762104,"score_spread":0.2799572102411311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}