{"id":"W2154141109","doi":"10.1128/aac.45.4.1184-1191.2001","title":"Amphotericin B Lipid Complex or Amphotericin B Multiple-Dose Administration to Rabbits with Elevated Plasma Cholesterol Levels: Pharmacokinetics in Plasma and Blood, Plasma Lipoprotein Levels, Distribution in Tissues, and Renal Toxicities","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Pharmacokinetics; Amphotericin B; Triglyceride; Cholesterol; Pharmacology; Creatinine; Lipoprotein; Blood plasma; Distribution (mathematics); Endocrinology; Toxicity; Internal medicine; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806816,0.0003830131,0.000663164,0.0003991122,0.0002207368,0.0003917713,0.0002326536,0.0003993781,0.0005291286],"category_scores_gemma":[0.0004108617,0.0002329394,0.0003362613,0.0002241256,0.0004190257,0.0004208887,0.0002309179,0.001021486,0.0002862538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004018909,"about_ca_system_score_gemma":0.0003132059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000545904,"about_ca_topic_score_gemma":0.0008842284,"domain_scores_codex":[0.9995728,0.00007259899,0.00005893234,0.00009712964,0.0001176379,0.00008089083],"domain_scores_gemma":[0.9995023,0.00005261915,0.0002067833,0.00008397185,0.00006938247,0.00008508071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001025223,0.0002503356,0.0007149132,0.00002939678,0.00001131035,0.00008074834,0.00003731065,0.00003439707,0.9953049,0.00004831734,0.00002464203,0.002438415],"study_design_scores_gemma":[0.0001595864,0.009594783,0.00848713,0.0000116105,0.00008385852,0.0007717813,0.00006311679,0.001018285,0.9778517,0.00005788824,0.001885721,0.00001458147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976387,0.0005560773,0.001243544,0.00005314359,0.00001708167,0.00003994775,0.00004625648,0.00003418287,0.0003711061],"genre_scores_gemma":[0.9933469,0.0008432563,0.003214365,0.0001030406,0.00002547901,0.000110378,0.0002324318,0.00002455741,0.002099595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000663164,"threshold_uncertainty_score":0.002915859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08963282707222787,"score_gpt":0.3636514857717986,"score_spread":0.2740186586995708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}