{"id":"W2154141109","doi":"10.1128/aac.45.4.1184-1191.2001","title":"Amphotericin B Lipid Complex or Amphotericin B Multiple-Dose Administration to Rabbits with Elevated Plasma Cholesterol Levels: Pharmacokinetics in Plasma and Blood, Plasma Lipoprotein Levels, Distribution in Tissues, and Renal Toxicities","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Pharmacokinetics; Amphotericin B; Triglyceride; Cholesterol; Pharmacology; Creatinine; Lipoprotein; Blood plasma; Distribution (mathematics); Endocrinology; Toxicity; Internal medicine; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003700254,0.0005485031,0.0006048176,0.0002228894,0.0002125478,0.00012755,0.0001937282,0.000300041,0.0002147408],"category_scores_gemma":[0.00002343485,0.0004840715,0.00003611631,0.0004457672,0.0002563415,0.0001582311,0.00009958596,0.0004898618,0.000005312614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005120151,"about_ca_system_score_gemma":0.0000752174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002499137,"about_ca_topic_score_gemma":0.001188722,"domain_scores_codex":[0.9974847,0.0002641162,0.0006613508,0.0007091615,0.0001906905,0.0006900172],"domain_scores_gemma":[0.9990966,0.0001274362,0.0002025307,0.0001617955,0.00007117134,0.0003404829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008432563,0.0009490289,0.03572937,0.0001236497,0.0001837474,0.0002510737,0.002155903,0.000324834,0.8477848,0.00001007888,0.001000178,0.1030548],"study_design_scores_gemma":[0.02801853,0.000819189,0.2341706,0.0001855694,0.0001397814,0.0004839434,0.0001401624,0.01441482,0.6074561,0.000008994465,0.1132974,0.0008648376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958923,0.00007118117,0.00009395737,0.001876172,0.0001973199,0.001184233,0.0005942081,0.00004979777,0.00004086777],"genre_scores_gemma":[0.9897843,0.003890527,0.0006539773,0.004872656,0.0001997059,0.00005508179,0.0001676799,0.00005925579,0.0003168405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2403287,"threshold_uncertainty_score":0.9997611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08963282707222787,"score_gpt":0.3636514857717986,"score_spread":0.2740186586995708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}