{"id":"W2154164205","doi":"10.1084/jem.20081588","title":"Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models","year":2008,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":365,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council; Michael Smith Health Research BC","keywords":"Senile plaques; Valproic Acid; Alzheimer's disease; Genetically modified mouse; In vivo; Amyloid precursor protein; Pathogenesis; Epilepsy; Neuroscience; Amyloid (mycology); Pharmacology; Transgene; Medicine; Biology; Disease; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003253916,0.0002146999,0.0003865899,0.0002661213,0.0001811079,0.000007064496,0.0001121739,0.00004043203,0.00004622733],"category_scores_gemma":[0.00006527542,0.0001290043,0.0000652943,0.0002261701,0.0004174775,0.0005529228,0.00005073856,0.0003024024,0.000006245671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001166022,"about_ca_system_score_gemma":0.0001833729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005810678,"about_ca_topic_score_gemma":0.000004274636,"domain_scores_codex":[0.9980698,0.0001422521,0.0005832249,0.0001602708,0.0007410963,0.0003033771],"domain_scores_gemma":[0.9987345,0.0000405163,0.0001954295,0.0002374344,0.0002022235,0.0005898459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06660533,0.03657069,0.1683202,0.0006563824,0.01204705,0.01831218,0.1024967,0.0009779248,0.5569984,0.0009963382,0.02851717,0.007501722],"study_design_scores_gemma":[0.03896892,0.01437893,0.0639362,0.002769476,0.005312035,0.02715921,0.01585784,0.001956742,0.8271872,0.001468061,0.0001062033,0.0008991108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9023139,0.09432328,0.00001586067,0.002557038,0.00009560236,0.0006053656,0.000005337336,0.00001445273,0.00006910347],"genre_scores_gemma":[0.9969638,0.002410992,0.00007523428,0.0002152327,0.0002500706,0.00002445087,0.00001610425,0.00002678262,0.00001731512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2701889,"threshold_uncertainty_score":0.5260643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0788467677541053,"score_gpt":0.3458781977640774,"score_spread":0.267031430009972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}