{"id":"W2154173380","doi":"10.1021/jm0101287","title":"Design and Synthesis of 4,5-Diphenyl-4-isoxazolines:  Novel Inhibitors of Cyclooxygenase-2 with Analgesic and Antiinflammatory Activity","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Analgesic; Cyclooxygenase; Pharmacology; Analgesic agents; Combinatorial chemistry; Stereochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001067095,0.000233081,0.0008759887,0.0001373363,0.00003773914,0.000004968734,0.00008671264,0.0001635908,0.00002416428],"category_scores_gemma":[0.0004638943,0.0001600767,0.00009045847,0.0001928121,0.0003973893,0.0001147594,0.00002604481,0.0003738672,1.665641e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004307891,"about_ca_system_score_gemma":0.0003380163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001087758,"about_ca_topic_score_gemma":7.815642e-7,"domain_scores_codex":[0.998278,0.0000458647,0.000635375,0.0001746006,0.0006495485,0.000216599],"domain_scores_gemma":[0.9977958,0.0004743455,0.0008962229,0.0001906323,0.000300725,0.0003422602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003831885,0.0003023665,0.04908415,0.002109451,0.0003000411,0.0005964079,0.0002789742,0.00002271821,0.9373449,0.000001914697,0.0001086425,0.006018557],"study_design_scores_gemma":[0.004383143,0.0008441693,0.04437442,0.002795153,0.0007124128,0.004760471,0.0005115371,0.0003944376,0.9409299,0.000008458323,0.0001103601,0.0001755541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970097,0.001398587,0.001017638,0.0001967097,0.00006228046,0.0001516183,0.000002471181,0.000007510173,0.0001534973],"genre_scores_gemma":[0.997241,0.0007089116,0.001533164,0.00002339287,0.0004408859,0.000002836772,4.506719e-7,0.00002409937,0.00002526644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005843002,"threshold_uncertainty_score":0.6527738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009889380612024722,"score_gpt":0.2298404832950064,"score_spread":0.2199511026829817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}