{"id":"W2154215306","doi":"10.1099/vir.0.024380-0","title":"Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein","year":2010,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; European Commission","keywords":"Chronic wasting disease; Biology; Virology; Transmission (telecommunications); Prion protein; Transgene; Disease; Horizontal transmission; Genetically modified mouse; Transmissible spongiform encephalopathy; Virus; Gene; Scrapie; Genetics; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961338,0.0003051167,0.0001838361,0.00025996,0.0001655019,0.0003959457,0.0001762502,0.0004347447,0.001088023],"category_scores_gemma":[0.0002313807,0.0001954198,0.0002094251,0.0001154772,0.000407158,0.0003440193,0.0001395907,0.0006792354,0.0003725873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777789,"about_ca_system_score_gemma":0.0001853599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005879306,"about_ca_topic_score_gemma":0.0007192807,"domain_scores_codex":[0.9997867,0.00003794551,0.00003432803,0.00005282582,0.00004249101,0.00004567815],"domain_scores_gemma":[0.9996197,0.00007732598,0.0001184689,0.00006232023,0.00003279144,0.00008936142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704183,0.00005033354,0.0003340943,0.00002102348,0.000009518714,0.000126267,0.00003160321,0.0000219135,0.998629,0.0001307746,0.00003367212,0.0004413885],"study_design_scores_gemma":[0.0003299239,0.002805515,0.02139726,0.00005415651,0.0001172365,0.005298594,0.000155658,0.00217985,0.9611505,0.0006074083,0.005883659,0.00002029992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971142,0.0005025003,0.001410673,0.00007329113,0.00002065273,0.00002144875,0.0002410257,0.00003853026,0.0005775514],"genre_scores_gemma":[0.994477,0.0007241564,0.001472029,0.0000791713,0.00001323757,0.00003578891,0.0008689156,0.00003366131,0.002296049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088023,"threshold_uncertainty_score":0.003639817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143480910873821,"score_gpt":0.2754224505545151,"score_spread":0.2639876414457769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}