{"id":"W2154245719","doi":"10.1186/1741-7015-8-13","title":"Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection","year":2010,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"","keywords":"Metabolomics; Medicine; Fourier transform ion cyclotron resonance; Colorectal cancer; Biomarker discovery; Polyunsaturated fatty acid; Tandem mass spectrometry; Degree of unsaturation; Biomarker; Selected reaction monitoring; Mass spectrometry; Oncology; Cancer; Metabolome; Internal medicine; Computational biology; Bioinformatics; Chromatography; Biochemistry; Metabolite; Proteomics; Biology; Fatty acid; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631536,0.00008676029,0.0001709423,0.0000604519,0.00004793061,0.000002559654,0.00008807454,0.00008237189,0.000004260144],"category_scores_gemma":[0.0003127928,0.00005825135,0.00002975308,0.0001625787,0.0001318519,0.000003012495,0.00001834819,0.00008091453,2.469163e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003535954,"about_ca_system_score_gemma":0.00002243103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00015176,"about_ca_topic_score_gemma":0.0009035756,"domain_scores_codex":[0.9993946,0.00003105056,0.0002278901,0.0001652153,0.00006384933,0.0001174007],"domain_scores_gemma":[0.9995106,0.00005335678,0.0001418138,0.0001353926,0.0001339584,0.00002483591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009691391,0.00002305352,0.1581122,0.00001821974,0.00002804379,2.190853e-8,0.0001283512,0.000001921016,0.8397083,0.00004421033,0.000008583208,0.001830167],"study_design_scores_gemma":[0.0007879453,0.0003085806,0.6306028,0.00001171813,0.00002321804,0.000001307686,0.00006888019,0.00002476789,0.3680612,0.00003803586,0.00003189654,0.00003966461],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965353,0.0003948028,0.002186871,0.0002868994,0.0001096228,0.0003521038,0.00009171968,0.000002609583,0.00004004124],"genre_scores_gemma":[0.9992294,0.000104593,0.0004632077,0.00003397803,0.00007234284,0.00004715036,0.0000290044,0.000007585085,0.00001277299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4724906,"threshold_uncertainty_score":0.2375421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818899266417709,"score_gpt":0.2838413417555279,"score_spread":0.2656523490913508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}