{"id":"W2154261852","doi":"10.1515/bc.2008.106","title":"Generation of transducible versions of transcription factors Oct4 and Sox2","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stem Cell Network","keywords":"SOX2; Embryonic stem cell; Cell biology; Fusion protein; Biology; Transcription factor; Stem cell; Transduction (biophysics); Gene knockdown; Homeobox protein NANOG; Recombinant DNA; Genetics; Gene; Induced pluripotent stem cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003807146,0.0005858472,0.0003194027,0.0002626727,0.0001634446,0.0003503197,0.000381752,0.0003671558,0.001079367],"category_scores_gemma":[0.0002499276,0.0002356779,0.0003128415,0.0002198389,0.0002726756,0.0003651062,0.0004472187,0.0006993441,0.0004648582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207946,"about_ca_system_score_gemma":0.0002473359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771106,"about_ca_topic_score_gemma":0.0003421735,"domain_scores_codex":[0.9997701,0.00004464285,0.00002986799,0.00004398562,0.00007960316,0.000031767],"domain_scores_gemma":[0.9998339,0.00003495707,0.00004928387,0.000029109,0.00002094986,0.00003176524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000247947,0.00001094874,0.00003258618,0.0000248988,0.000003100492,0.00002872061,0.000009729081,0.00007571733,0.9988229,0.0002981666,0.00001796978,0.0006506086],"study_design_scores_gemma":[0.00001338141,0.0001079022,0.0002876518,0.000002488803,0.00001177965,0.0001268543,0.000007438163,0.0006046241,0.9953806,0.00006959334,0.003382309,0.000005399919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9337288,0.00150322,0.05968259,0.0001826073,0.0001126698,0.000255743,0.001267967,0.000288896,0.002977651],"genre_scores_gemma":[0.9381378,0.002098827,0.04459713,0.00008706949,0.00002923614,0.0002109486,0.003164701,0.0001779468,0.0114964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079367,"threshold_uncertainty_score":0.003610909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1016691063741379,"score_gpt":0.2783144830738981,"score_spread":0.1766453766997602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}