{"id":"W2154261852","doi":"10.1515/bc.2008.106","title":"Generation of transducible versions of transcription factors Oct4 and Sox2","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stem Cell Network","keywords":"SOX2; Embryonic stem cell; Cell biology; Fusion protein; Biology; Transcription factor; Stem cell; Transduction (biophysics); Gene knockdown; Homeobox protein NANOG; Recombinant DNA; Genetics; Gene; Induced pluripotent stem cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007470439,0.00008946504,0.0001348854,0.00001157534,0.00004539832,0.000001632178,0.00009626614,0.0002067192,0.00006348269],"category_scores_gemma":[0.00004887556,0.0000701996,0.00007547528,0.00005252551,0.0002273724,0.00000231376,0.00002828469,0.00006085874,5.49447e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005427189,"about_ca_system_score_gemma":0.00003065011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009438091,"about_ca_topic_score_gemma":7.21383e-7,"domain_scores_codex":[0.999352,0.00002751818,0.0001727071,0.0002263073,0.0000972397,0.0001242643],"domain_scores_gemma":[0.9996791,0.00001087411,0.00004774865,0.0001463081,0.00005459637,0.00006135657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004493923,0.00006700531,0.008176746,0.00004222123,0.00001603153,9.315289e-7,0.0000301202,0.000008417709,0.9913857,0.000002863551,0.0001317962,0.00009322259],"study_design_scores_gemma":[0.0002765546,0.0001413993,0.008205891,0.000005128857,0.000005178024,0.000009225539,0.00004241172,0.00002821606,0.9902983,0.000005080004,0.0009080116,0.00007460832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998391,0.0006690092,0.0002483662,0.0000247945,0.00001836994,0.00006899826,0.00004814389,0.000005147334,0.0005261315],"genre_scores_gemma":[0.9982009,0.001103456,0.0001654611,0.00000689742,0.00004849835,0.000003532565,0.0002412735,0.000004625063,0.0002253889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087409,"threshold_uncertainty_score":0.2862656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1016691063741379,"score_gpt":0.2783144830738981,"score_spread":0.1766453766997602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}