{"id":"W2154296834","doi":"10.1186/1745-6215-10-49","title":"Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)","year":2009,"lang":"en","type":"article","venue":"Trials","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; St. Michael's Hospital; Western University; AIDS Vancouver; University of British Columbia; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; McMaster University","funders":"Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Interim; Medicine; Protocol (science); Interim analysis; Truncation (statistics); Randomized controlled trial; Data monitoring committee; Research design; Early stopping; Clinical trial; Medical physics; Alternative medicine; Statistics; Internal medicine; Computer science; Law; Artificial intelligence; Pathology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4945817,0.008248786,0.01069936,0.01089382,0.005467983,0.01107967,0.007633673,0.02809273,0.0349304],"category_scores_gemma":[0.5991198,0.005933761,0.02284572,0.01156269,0.01239986,0.01016493,0.01235238,0.0312954,0.01723036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009068333,"about_ca_system_score_gemma":0.05621175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001190364,"about_ca_topic_score_gemma":0.002138888,"domain_scores_codex":[0.3814504,0.5150368,0.07039427,0.01306144,0.01678319,0.003273735],"domain_scores_gemma":[0.3981172,0.4048672,0.03931553,0.08921626,0.05929611,0.009187669],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0802501,0.002778113,0.00305074,0.1487659,0.01168713,0.002101357,0.0196401,0.009959457,0.004766763,0.2531029,0.1636322,0.3002654],"study_design_scores_gemma":[0.1012459,0.008108757,0.002807139,0.09066968,0.006467627,0.0009977113,0.001521453,0.01624718,0.004823789,0.2346698,0.5312576,0.001183385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0007513546,0.001679437,0.09919907,0.004817146,0.003941426,0.8841217,0.001992462,0.0006177554,0.002879653],"genre_scores_gemma":[0.000860439,0.0003382864,0.06942523,0.001090809,0.0001620053,0.9275262,0.0002319955,0.00003924842,0.0003258891],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.5054183,"threshold_uncertainty_score":0.6232708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8236072502114632,"score_gpt":0.6884190417043091,"score_spread":0.1351882085071541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}