{"id":"W2154339166","doi":"10.1186/bcr3434","title":"COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration","year":2013,"lang":"en","type":"letter","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Cancer Institute; National Breast Cancer Foundation; Susan G. Komen; National Health and Medical Research Council; Breast Cancer Research Foundation","keywords":"Breast cancer; Missing heritability problem; Heritability; Genetic architecture; Genetic association; Genetics; Positional cloning; Candidate gene; Genetic variation; Allele; Genome-wide association study; Biology; Surgical oncology; Genetic testing; Cancer; Bioinformatics; Medicine; Oncology; Gene; Genotype; Genetic variants; Single-nucleotide polymorphism; Quantitative trait locus; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000971253,0.0003593858,0.0003668561,0.0001752192,0.0005471389,0.0003802295,0.0008182102,0.0007112695,0.001248065],"category_scores_gemma":[0.00005303075,0.000301944,0.0001562784,0.0007485762,0.0007056412,0.00003812681,0.0003476892,0.001199795,0.00002450306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009630363,"about_ca_system_score_gemma":0.002822717,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009044658,"about_ca_topic_score_gemma":0.002316475,"domain_scores_codex":[0.9957464,0.000871709,0.0005928392,0.0009244363,0.001163328,0.0007012683],"domain_scores_gemma":[0.9954604,0.00007520949,0.0003296402,0.00116541,0.002882212,0.00008712897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006119676,0.00003029265,0.0004140712,0.0002720693,0.0001637347,0.000002714168,0.000164893,0.0002244486,0.3703265,0.000005318572,0.6072816,0.02105319],"study_design_scores_gemma":[0.001569224,0.0001585998,0.03482302,0.0007046959,0.000248408,0.0003570119,0.0008351484,0.004732456,0.1047309,0.0004839743,0.8497671,0.001589362],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08711169,0.0115992,0.000978439,0.8923919,0.00179886,0.002286087,0.003495041,0.00003227486,0.00030656],"genre_scores_gemma":[0.8926414,0.003036542,0.0008384176,0.06273559,0.02976945,0.004144292,0.003024705,0.0003443443,0.003465249],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8296562,"threshold_uncertainty_score":0.9999433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1211058081385211,"score_gpt":0.4025293785426623,"score_spread":0.2814235704041411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}