{"id":"W2154407581","doi":"10.1016/j.immuni.2008.10.017","title":"Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim","year":2009,"lang":"en","type":"article","venue":"Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Health and Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Leukemia and Lymphoma Society","keywords":"Tumor necrosis factor alpha; Biology; Apoptosis; Hepatocyte; Caspase; Effector; Liver injury; Necrosis; Caspase 8; Cancer research; Immune system; Immunology; Lipopolysaccharide; Fas ligand; Programmed cell death; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003804573,0.0004379859,0.000298225,0.0003303467,0.0003020531,0.0004388744,0.0001831396,0.0002321393,0.001605854],"category_scores_gemma":[0.000319304,0.0001914921,0.0002958683,0.0001212875,0.000320156,0.0004398845,0.0003858877,0.0005442688,0.0007097722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473734,"about_ca_system_score_gemma":0.0002003079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001784068,"about_ca_topic_score_gemma":0.0001493373,"domain_scores_codex":[0.9997298,0.00006040372,0.00002500738,0.00002862547,0.00006535032,0.00009079882],"domain_scores_gemma":[0.9996498,0.00003113658,0.00009708303,0.0000908074,0.00004247753,0.00008869471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00123416,0.00008384036,0.001452291,0.00006099382,0.00001610679,0.0006116721,0.00004739624,0.0001322813,0.990515,0.001215605,0.0002077435,0.004422944],"study_design_scores_gemma":[0.0001980456,0.001173565,0.02305725,0.00002577154,0.00004076046,0.005714011,0.000161588,0.002120519,0.9609229,0.002509758,0.004053628,0.00002214282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851428,0.002444311,0.007866783,0.0001972478,0.00009477168,0.00003714953,0.0002042118,0.0003114024,0.003701394],"genre_scores_gemma":[0.9974036,0.0003506252,0.0005419601,0.00002626178,0.000009397977,0.000009928002,0.0001666499,0.00001306987,0.001478547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605854,"threshold_uncertainty_score":0.005372167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008551722656058093,"score_gpt":0.2236169424765285,"score_spread":0.2150652198204704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}