{"id":"W2154421528","doi":"10.1093/hmg/ddq543","title":"TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Eye Institute; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Moorfields Eye Hospital NHS Foundation Trust; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Cilium; Biology; Cell biology; Retinal degeneration; Zebrafish; Basal body; Retina; Centrosome; Ciliogenesis; Retinal pigment epithelium; Retinal; Retinitis pigmentosa; Genetics; Gene; Neuroscience; Flagellum; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743324,0.0009362057,0.0003674242,0.0008986108,0.0006235341,0.0006291554,0.0003322978,0.0006218458,0.001137354],"category_scores_gemma":[0.0002793955,0.0001501304,0.0003977341,0.0005409827,0.0006018913,0.0002927841,0.000603956,0.0004046473,0.0007002241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005817423,"about_ca_system_score_gemma":0.0003877725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002176563,"about_ca_topic_score_gemma":0.001356665,"domain_scores_codex":[0.9998114,0.00001259821,0.000018918,0.00004535873,0.00007816542,0.00003359882],"domain_scores_gemma":[0.99975,0.00001704011,0.000119111,0.00001143373,0.00004079026,0.0000616865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005324068,0.00003248372,0.0158864,0.0005232121,0.0001625156,0.01116802,0.00008527953,0.0004619822,0.9348555,0.001664347,0.002173627,0.03245422],"study_design_scores_gemma":[0.00008662788,0.0005485399,0.1133127,0.0001464908,0.0005717762,0.0506223,0.0002560617,0.002485543,0.7301579,0.001668802,0.1000539,0.00008943231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8663573,0.09853762,0.0179113,0.00110182,0.0008284793,0.0001253357,0.00377355,0.001226674,0.01013784],"genre_scores_gemma":[0.9776778,0.01291231,0.003689606,0.000134109,0.00009715561,0.00001551973,0.001646885,0.00004022119,0.003786478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176563,"threshold_uncertainty_score":0.004327834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006381385885040508,"score_gpt":0.2469477175115599,"score_spread":0.2405663316265194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}