{"id":"W2154421528","doi":"10.1093/hmg/ddq543","title":"TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Eye Institute; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Moorfields Eye Hospital NHS Foundation Trust; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Cilium; Biology; Cell biology; Retinal degeneration; Zebrafish; Basal body; Retina; Centrosome; Ciliogenesis; Retinal pigment epithelium; Retinal; Retinitis pigmentosa; Genetics; Gene; Neuroscience; Flagellum; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001213593,0.0002718017,0.0001765293,0.00007601027,0.0001141652,0.00005884798,0.0003460208,0.0002654949,0.0001678826],"category_scores_gemma":[0.00006211899,0.0002982607,0.0001230884,0.0001424758,0.0001341335,0.000002530249,0.000148373,0.000205495,0.00002905219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001167768,"about_ca_system_score_gemma":0.0001771075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002088651,"about_ca_topic_score_gemma":0.0001094354,"domain_scores_codex":[0.9982675,0.00007205323,0.0003712815,0.0006077297,0.0002374817,0.0004439769],"domain_scores_gemma":[0.9987687,0.000002065281,0.00009518059,0.0007480915,0.0001435292,0.0002423596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002808128,0.0001288583,0.006656104,0.00001417057,0.00001847349,0.00001985044,0.00003812144,0.00002710051,0.9909413,0.0003086793,0.001607265,0.0002119917],"study_design_scores_gemma":[0.0009080663,0.0002229224,0.03280156,0.00001048189,0.00002372856,0.00002199528,0.00002087406,0.00007062581,0.9485552,0.0008010896,0.01618083,0.0003826605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966568,0.0006026163,0.0009304126,0.000243192,0.00008837683,0.0005166499,0.00003819647,0.00002126073,0.000902544],"genre_scores_gemma":[0.9949046,0.00002434302,0.003123384,0.0007654734,0.0002139709,0.00009474817,0.0003307055,0.00005208682,0.0004906799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04238614,"threshold_uncertainty_score":0.999947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006381385885040508,"score_gpt":0.2469477175115599,"score_spread":0.2405663316265194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}