{"id":"W2154422767","doi":"10.1126/science.1251343","title":"Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Biotechnology and Biological Sciences Research Council; Rosetrees Trust; Wellcome Trust; Academy of Medical Sciences; National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK","keywords":"Retrotransposon; Biology; Somatic cell; Genome; Mobile genetic elements; Germline; Carcinogenesis; Genetics; Gene; Computational biology; Human genome; Transduction (biophysics); Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008376701,0.0004599603,0.0004519825,0.001520371,0.0004278086,0.0009275594,0.0005422715,0.0004623188,0.001416996],"category_scores_gemma":[0.002335571,0.0002147464,0.0005802216,0.00104754,0.000299047,0.000377281,0.00053971,0.0003652772,0.0005498779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004829989,"about_ca_system_score_gemma":0.0005562132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377804,"about_ca_topic_score_gemma":0.00195762,"domain_scores_codex":[0.9993742,0.0001007945,0.00005249193,0.0002325128,0.0001962883,0.00004360212],"domain_scores_gemma":[0.9991716,0.0003762123,0.0002396312,0.00005535875,0.0001059842,0.00005115996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009723568,0.0003275381,0.351469,0.0006405708,0.0003811241,0.0009507054,0.0005232573,0.07532298,0.1750176,0.00330484,0.001944194,0.3891459],"study_design_scores_gemma":[0.0000709445,0.0004129579,0.1168083,0.0001156922,0.0002053975,0.0033077,0.0002691215,0.7917709,0.07497647,0.006013806,0.005994695,0.00005401544],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8270667,0.000958,0.166331,0.0001846279,0.00002020736,0.0001550149,0.0008246065,0.002593578,0.00186626],"genre_scores_gemma":[0.8434137,0.0002565831,0.1534234,0.000106635,0.00001545689,0.00007391848,0.001925106,0.0001288596,0.0006564034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520371,"threshold_uncertainty_score":0.004740357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089583473529833,"score_gpt":0.2255579641260868,"score_spread":0.2146621293907884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}