{"id":"W2154422767","doi":"10.1126/science.1251343","title":"Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Biotechnology and Biological Sciences Research Council; Rosetrees Trust; Wellcome Trust; Academy of Medical Sciences; National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK","keywords":"Retrotransposon; Biology; Somatic cell; Genome; Mobile genetic elements; Germline; Carcinogenesis; Genetics; Gene; Computational biology; Human genome; Transduction (biophysics); Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275257,0.00005341952,0.00008230063,0.00001672757,0.00009776591,0.00001194488,0.0001353439,0.00003046093,0.0002502128],"category_scores_gemma":[0.00003919179,0.00002310212,0.00002368267,0.0006949949,0.0002028656,0.000115914,0.00000850207,0.00003999559,0.000005221687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002737301,"about_ca_system_score_gemma":0.00001643153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003335699,"about_ca_topic_score_gemma":0.00112295,"domain_scores_codex":[0.9992827,0.0000331087,0.0001252511,0.0002117617,0.0001992035,0.0001480339],"domain_scores_gemma":[0.9997082,0.00005829246,0.00004733686,0.00002975883,0.0001105526,0.00004580397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000005829105,0.00002902109,0.002943425,0.00000155304,7.965626e-7,1.152351e-7,0.0002213888,0.00002233915,0.9798579,0.0001056674,0.000004899503,0.01680708],"study_design_scores_gemma":[0.0001253523,0.0001939916,0.7488273,0.00002457817,0.000004928593,0.000001318534,0.0001677293,0.0005091175,0.2475326,0.0006404015,0.001873709,0.00009902714],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978302,0.0001151907,0.00004752686,0.001331034,0.00009607638,0.00009951374,0.00006746026,0.00001111792,0.0004018713],"genre_scores_gemma":[0.9996238,0.0001186356,0.00006861399,0.00008022761,0.00004530562,0.0000117134,0.00002071433,2.64251e-7,0.00003068955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7458838,"threshold_uncertainty_score":0.2739654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089583473529833,"score_gpt":0.2255579641260868,"score_spread":0.2146621293907884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}