{"id":"W2154431772","doi":"10.1042/bj20051931","title":"Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Protein tyrosine phosphatase; Phosphatase; Chemistry; Kinase; Active site; Biochemistry; Stereochemistry; Phosphorylation; Protein structure; Salt bridge; Tyrosine; Enzyme; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702639,0.0002658508,0.0003330221,0.000138682,0.0001197454,0.0002352944,0.0003544994,0.0002433669,0.0008840464],"category_scores_gemma":[0.0002442423,0.0001314199,0.0002082996,0.0002721383,0.00008510327,0.0001474294,0.0001230311,0.0003626926,0.0002241666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005792844,"about_ca_system_score_gemma":0.0003528336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867417,"about_ca_topic_score_gemma":0.002630968,"domain_scores_codex":[0.9998764,0.00001588759,0.00001152812,0.00002057925,0.00006161233,0.00001394745],"domain_scores_gemma":[0.9999436,0.000008685583,0.00001222574,0.000003935811,0.00001696846,0.00001452416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008363844,0.0002246541,0.003508287,0.0007767152,0.0001279623,0.0003492013,0.0001338003,0.004401996,0.9603844,0.0009131357,0.002416846,0.02592647],"study_design_scores_gemma":[0.0008776039,0.001240901,0.02361108,0.00007525219,0.0003346924,0.002123385,0.0001619981,0.030632,0.8945706,0.0002570959,0.0460696,0.00004576153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98241,0.009975532,0.002710175,0.0002127409,0.00003264293,0.00008577708,0.001805095,0.0001354866,0.00263262],"genre_scores_gemma":[0.9709835,0.006370319,0.0103123,0.00009370746,0.00001719447,0.00008231516,0.009486733,0.00002783283,0.002626054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001867417,"threshold_uncertainty_score":0.004203022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009983651844956408,"score_gpt":0.2450268557451573,"score_spread":0.2350432039002008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}