{"id":"W2154435279","doi":"10.1128/iai.73.3.1625-1634.2005","title":"Monocytes Are Highly Sensitive to<i>Clostridium difficile</i>Toxin A-Induced Apoptotic and Nonapoptotic Cell Death","year":2005,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Guts UK; Fondation pour la Recherche Médicale","keywords":"Propidium iodide; Toxin; Biology; Apoptosis; Programmed cell death; Clostridium difficile toxin A; Microbiology; Flow cytometry; Extracellular; Monocyte; Molecular biology; Cytochrome c; Lactate dehydrogenase; Mitochondrial permeability transition pore; Biochemistry; Clostridium difficile; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927136,0.0001960512,0.0002588298,0.0001548697,0.0001963975,0.0003042546,0.00008812946,0.0002356795,0.001000944],"category_scores_gemma":[0.0001985475,0.0001094178,0.0001592319,0.0001853187,0.0001324334,0.0001047524,0.0001863999,0.000253393,0.000504092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463034,"about_ca_system_score_gemma":0.0001546906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004869641,"about_ca_topic_score_gemma":0.0007644686,"domain_scores_codex":[0.9997081,0.00008023928,0.00002743328,0.00003441468,0.00006735593,0.00008242892],"domain_scores_gemma":[0.9998141,0.00004013306,0.00004928971,0.00002032908,0.00005133649,0.00002481212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004830862,0.00003786042,0.0019856,0.0001306954,0.000008446545,0.0003803986,0.0001191891,0.0000322493,0.9916089,0.000085321,0.00007039992,0.005057817],"study_design_scores_gemma":[0.00006810424,0.002830246,0.0784733,0.00007546076,0.00008873458,0.004079563,0.0004698021,0.0004770896,0.900866,0.0002713223,0.01227879,0.0000217107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837854,0.008962892,0.004646374,0.000109647,0.00005280688,0.0000880404,0.0002678498,0.00005096869,0.00203605],"genre_scores_gemma":[0.9902332,0.003428659,0.003424958,0.0001585686,0.00003261975,0.00007772813,0.0004721721,0.000007070396,0.002165083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001000944,"threshold_uncertainty_score":0.00334847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02965309380388416,"score_gpt":0.2888990405503855,"score_spread":0.2592459467465014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}