{"id":"W2154439306","doi":"10.1073/pnas.0500099102","title":"Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death <i>in vitro</i> and <i>in vivo</i>","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canadian Stroke Network; Canadian Institutes of Health Research; National Institute on Aging; Université Laval; Heart and Stroke Foundation of Canada","keywords":"Kinase; Cell biology; Biology; Cyclin-dependent kinase 5; Retinoblastoma protein; Cell cycle; Programmed cell death; Activator (genetics); Cyclin-dependent kinase; Regulator; Ischemia; Neuroscience; Cancer research; Apoptosis; Protein kinase A; Cyclin-dependent kinase 2; Medicine; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009283027,0.000130122,0.0003212035,0.0002876254,0.00004993658,0.000008749792,0.0003112311,0.0001302295,0.00001520588],"category_scores_gemma":[0.00213101,0.00009921005,0.00008257261,0.0005762569,0.0007604927,0.0002534565,0.0001208016,0.0003080844,4.860314e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006910042,"about_ca_system_score_gemma":0.00008451984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001252947,"about_ca_topic_score_gemma":0.00000104199,"domain_scores_codex":[0.9975572,0.00001026297,0.0005389612,0.0003270629,0.001344589,0.0002218721],"domain_scores_gemma":[0.9990154,0.000380303,0.0003106808,0.00001350905,0.0002008726,0.00007922458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432193,0.0001671055,0.02848589,0.0001252611,0.000007509111,1.479575e-7,0.00008240355,0.0001520127,0.9698091,0.000763326,0.0001388737,0.0001251694],"study_design_scores_gemma":[0.0008878691,0.00005744695,0.03792615,0.0003093123,0.00002305781,0.00002562252,0.0001122081,0.001475933,0.9577304,0.001294267,0.00007481188,0.00008296136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930634,0.0007436657,7.849265e-7,0.004666858,0.00001878465,0.0002403498,0.00004555343,0.000007889772,0.001212742],"genre_scores_gemma":[0.9980046,0.0001003926,0.001144709,0.0006299475,0.00007758241,0.00001382727,1.828404e-7,0.000007832148,0.00002093394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01207872,"threshold_uncertainty_score":0.4045668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805735856609359,"score_gpt":0.3001135180914148,"score_spread":0.2720561595253213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}