{"id":"W2154466433","doi":"10.1002/btpr.8","title":"High yields of monomeric recombinant β‐interferon from macroporous microcarrier cultures under hypothermic conditions","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Microcarrier; Chinese hamster ovary cell; Bioreactor; Recombinant DNA; Cell culture; Titer; Suspension (topology); Chemistry; Suspension culture; Interferon; Biology; Biochemistry; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002741267,0.0002001139,0.0002325545,0.00007627483,0.000176915,0.000008244704,0.0002847284,0.000566407,0.0001129761],"category_scores_gemma":[0.00001744807,0.000174044,0.0001281014,0.0001181464,0.0006775252,0.000004824621,0.0001615806,0.0001446835,0.00001844504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001637458,"about_ca_system_score_gemma":0.00005101686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001862286,"about_ca_topic_score_gemma":0.00002444397,"domain_scores_codex":[0.9989463,0.00004237232,0.0002631616,0.0004164867,0.00007815823,0.0002535364],"domain_scores_gemma":[0.9992043,0.000007717496,0.0001752397,0.0004869789,0.00006315045,0.00006257807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141027,0.0002768329,0.003424988,0.0000115369,0.0001737174,0.0000165696,0.00003604485,0.00002763694,0.9828135,0.0004578111,0.0108774,0.001742928],"study_design_scores_gemma":[0.000683501,0.0008316425,0.005571705,0.00002872656,0.00003258764,0.00007615043,0.00007256765,0.000007267521,0.982022,0.001177336,0.00923794,0.000258515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939622,0.004337714,0.0003233993,0.0004599935,0.0004492921,0.0002056036,0.0001288759,0.00007345925,0.00005950952],"genre_scores_gemma":[0.9972886,0.001060486,0.000722893,0.0001852895,0.00009312462,0.00006754386,0.0001934327,0.00002815582,0.0003604343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003326487,"threshold_uncertainty_score":0.7097307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009799053416315581,"score_gpt":0.2520981221194562,"score_spread":0.2422990687031406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}