{"id":"W2154466433","doi":"10.1002/btpr.8","title":"High yields of monomeric recombinant β‐interferon from macroporous microcarrier cultures under hypothermic conditions","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Microcarrier; Chinese hamster ovary cell; Bioreactor; Recombinant DNA; Cell culture; Titer; Suspension (topology); Chemistry; Suspension culture; Interferon; Biology; Biochemistry; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003224368,0.0004469582,0.0003423974,0.0001801374,0.0001516833,0.0003664971,0.0002100539,0.0002517994,0.0005296584],"category_scores_gemma":[0.0002287536,0.0001489867,0.0002378942,0.0001986113,0.0001796728,0.0002278201,0.0002755233,0.0005800572,0.0004421877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132707,"about_ca_system_score_gemma":0.0001566247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003706469,"about_ca_topic_score_gemma":0.0005746577,"domain_scores_codex":[0.9998327,0.00003302388,0.00001539849,0.00003781958,0.00005604703,0.00002504279],"domain_scores_gemma":[0.9998558,0.0000403811,0.0000350736,0.00002333244,0.00002685706,0.00001860189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001391599,0.00000306672,0.00003016984,0.000007989051,0.000001586389,0.000008949881,0.000008304328,0.00003239697,0.9994629,0.00001558091,0.000006515742,0.0004085879],"study_design_scores_gemma":[0.000001967204,0.00005169498,0.0003657729,0.000002505728,0.000006171318,0.00003362394,0.000005801488,0.0002486129,0.9988027,0.0000115723,0.0004681389,0.000001440933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654999,0.001737673,0.02934869,0.00009166379,0.0000562851,0.0001047714,0.0004754378,0.0002079724,0.002477583],"genre_scores_gemma":[0.9625818,0.001531214,0.03011715,0.00004793251,0.00002636304,0.0001092976,0.001094638,0.0001131305,0.004378483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005296584,"threshold_uncertainty_score":0.002272904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009799053416315581,"score_gpt":0.2520981221194562,"score_spread":0.2422990687031406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}