{"id":"W2154479586","doi":"10.1080/08820130701555035","title":"Impaired Interleukin-2 Synthesis and T Cell Proliferation Following Antibody-mediated CD3 and CD2 or CD28 Cross-linking in<i>Trans</i>: Evidence that T Cell Activation Requires the Engagement of Costimulatory Molecules Within the Immunological Synapse","year":2008,"lang":"en","type":"article","venue":"Immunological Investigations","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"CD28; T cell; Immunological synapse; Interleukin 2; CD3; Biology; Molecular biology; Cell biology; Monoclonal antibody; Antigen-presenting cell; Aldesleukin; Antigen; Antibody; Chemistry; CD8; Cytokine; Immunology; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541273,0.000757787,0.0003787193,0.0002636163,0.0001196247,0.0003699682,0.0002311474,0.0005174024,0.001083144],"category_scores_gemma":[0.0001846095,0.0002611599,0.0003572617,0.0002047756,0.0003590059,0.0002392384,0.0002765708,0.0008621575,0.0005165386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825107,"about_ca_system_score_gemma":0.0002162567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006912532,"about_ca_topic_score_gemma":0.0007018366,"domain_scores_codex":[0.9995981,0.0000653642,0.00004498903,0.00007545648,0.0001049309,0.0001110832],"domain_scores_gemma":[0.9996852,0.00006188991,0.00009034503,0.00003899813,0.00003348634,0.00009012318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000821218,0.000007728779,0.00004315926,0.00001058223,0.000001712081,0.00001492459,0.000004984643,0.00001588791,0.9997042,0.00000797795,0.000002392121,0.000104359],"study_design_scores_gemma":[0.000009306176,0.0002185763,0.001299118,0.000001409804,0.000009306284,0.00008863623,0.000007190516,0.0002573516,0.9979089,0.000008778226,0.0001892525,0.000002262354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964157,0.0006374673,0.002024338,0.00002064645,0.00002361867,0.00001881337,0.0001939073,0.0000529164,0.0006126012],"genre_scores_gemma":[0.9965848,0.0002992608,0.001366508,0.00003484968,0.00001176708,0.00004746771,0.0004597943,0.00003018428,0.001165302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083144,"threshold_uncertainty_score":0.003623426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06608621317884078,"score_gpt":0.2849764328354292,"score_spread":0.2188902196565884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}