{"id":"W2154479586","doi":"10.1080/08820130701555035","title":"Impaired Interleukin-2 Synthesis and T Cell Proliferation Following Antibody-mediated CD3 and CD2 or CD28 Cross-linking in<i>Trans</i>: Evidence that T Cell Activation Requires the Engagement of Costimulatory Molecules Within the Immunological Synapse","year":2008,"lang":"en","type":"article","venue":"Immunological Investigations","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"CD28; T cell; Immunological synapse; Interleukin 2; CD3; Biology; Molecular biology; Cell biology; Monoclonal antibody; Antigen-presenting cell; Aldesleukin; Antigen; Antibody; Chemistry; CD8; Cytokine; Immunology; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001251917,0.0004125243,0.0005422846,0.0001820287,0.001253494,0.0000720122,0.0005408052,0.0005959634,0.00007505655],"category_scores_gemma":[0.001929222,0.0002323403,0.000141704,0.0003678683,0.003304141,0.0004888804,0.0003403311,0.001093157,0.00001783436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007959167,"about_ca_system_score_gemma":0.0001664353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000173161,"about_ca_topic_score_gemma":0.00002278757,"domain_scores_codex":[0.9962467,0.00165321,0.000884625,0.0005445554,0.0001318146,0.0005391128],"domain_scores_gemma":[0.994468,0.004301232,0.0005776442,0.0005042021,0.0001095105,0.00003937865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003492127,0.0002764957,0.04261042,0.00004387517,0.0001448793,0.00001307078,0.003361848,0.00008770109,0.9523167,0.0003499089,0.00001213419,0.0004337396],"study_design_scores_gemma":[0.001207997,0.0004544139,0.1051981,0.0003117194,0.0001048211,0.00009561156,0.001598486,0.0001195303,0.8899765,0.0003416195,0.0002641439,0.0003270897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818562,0.01543891,0.0003451401,0.0009416268,0.0002790013,0.0009425299,0.00001631485,0.0001116291,0.00006870825],"genre_scores_gemma":[0.9967179,0.002208421,0.000275543,0.000315502,0.00001687506,0.0002241399,0.00008014192,0.00002379057,0.0001376319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06258766,"threshold_uncertainty_score":0.9994083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06608621317884078,"score_gpt":0.2849764328354292,"score_spread":0.2188902196565884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}