{"id":"W2154482916","doi":"10.4061/2010/417314","title":"Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model","year":2010,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada)","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek","keywords":"Genetically modified mouse; Pathological; Transgene; Disease; Neuroscience; Parallels; Medicine; Psychology; Pathology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008225645,0.0002799868,0.0005108596,0.0002164289,0.00007977116,0.00004670979,0.0005143338,0.00009952407,0.00003747109],"category_scores_gemma":[0.001048929,0.0001865686,0.0006577723,0.0001323474,0.0004299169,0.0002690642,0.0001380839,0.0006386722,0.000002961944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003051581,"about_ca_system_score_gemma":0.001137071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002355395,"about_ca_topic_score_gemma":0.00001015709,"domain_scores_codex":[0.9969435,0.0001830014,0.001113309,0.0003742126,0.00102829,0.0003576672],"domain_scores_gemma":[0.9966964,0.0004600914,0.0004949191,0.0003613567,0.0007959278,0.001191317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01794989,0.007805305,0.9285053,0.00007535785,0.01555503,0.000937371,0.0001892527,0.001505544,0.0008934356,0.001849185,0.0008945917,0.02383972],"study_design_scores_gemma":[0.01190335,0.0003666992,0.9483282,0.0003106436,0.006982782,0.00007382916,0.00004510962,0.02494842,0.0009890833,0.005574794,0.0001392162,0.0003378658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820607,0.01270257,0.0001041432,0.003489447,0.0003811924,0.0008332822,0.0003486498,0.00001646281,0.00006350704],"genre_scores_gemma":[0.9959546,0.0003614891,0.002790096,0.0004151385,0.0003432174,0.00004696447,0.00003723439,0.00003859223,0.00001266351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02350185,"threshold_uncertainty_score":0.7608047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0702551212589878,"score_gpt":0.3765276029776079,"score_spread":0.3062724817186201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}