{"id":"W2154482916","doi":"10.4061/2010/417314","title":"Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model","year":2010,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada)","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek","keywords":"Genetically modified mouse; Pathological; Transgene; Disease; Neuroscience; Parallels; Medicine; Psychology; Pathology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236282,0.0004953688,0.0007493354,0.0005653894,0.000217545,0.0005811545,0.0003197326,0.00071715,0.001063466],"category_scores_gemma":[0.0009550247,0.0001603784,0.000171638,0.0002596742,0.0006496137,0.0006989054,0.0002118041,0.0008705511,0.0003235546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771211,"about_ca_system_score_gemma":0.0003110378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001879088,"about_ca_topic_score_gemma":0.0004729164,"domain_scores_codex":[0.9997556,0.0001038844,0.0000289343,0.00003005717,0.00006347794,0.00001799547],"domain_scores_gemma":[0.9994857,0.0001586839,0.0001057237,0.00006266591,0.00009685314,0.00009036578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01518903,0.002684919,0.0145764,0.0006814144,0.0001139141,0.003596688,0.0001353739,0.0006285592,0.8293509,0.003041316,0.001950166,0.1280512],"study_design_scores_gemma":[0.00446644,0.1083836,0.1366464,0.0005625223,0.001497118,0.0372863,0.0004614605,0.006128235,0.6321229,0.01232114,0.05986333,0.0002603867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269719,0.05030747,0.003598878,0.003030634,0.0002356786,0.0002827405,0.0005441139,0.0002364073,0.01479214],"genre_scores_gemma":[0.9782808,0.01484608,0.003098555,0.0005748649,0.0001580681,0.0001106828,0.000430998,0.00002270231,0.002477349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236282,"threshold_uncertainty_score":0.006538153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0702551212589878,"score_gpt":0.3765276029776079,"score_spread":0.3062724817186201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}