{"id":"W2154483748","doi":"10.1093/humupd/dmn060","title":"Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review","year":2008,"lang":"en","type":"review","venue":"Human Reproduction Update","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Health Canada","funders":"","keywords":"Proprotein convertase; Kexin; Subtilisin; Proprotein Convertases; Biology; Furin; PCSK9; Biochemistry; Proteolysis; Cell biology; Chemistry; Enzyme; Cholesterol; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005981534,0.0007003716,0.001013277,0.003060286,0.0002167723,0.0009352614,0.0006822519,0.0008258861,0.003487446],"category_scores_gemma":[0.0009297963,0.0002103726,0.0004947282,0.003477836,0.0002657109,0.001084463,0.0004594839,0.00101536,0.00127923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000447094,"about_ca_system_score_gemma":0.001501808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009372726,"about_ca_topic_score_gemma":0.00124725,"domain_scores_codex":[0.9998209,0.00002957477,0.00004628742,0.00002918593,0.0000562471,0.00001788125],"domain_scores_gemma":[0.9994166,0.0002617608,0.000131783,0.00001168663,0.0001314427,0.0000467553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001285241,0.00005987085,0.0005422767,0.0380289,0.000179419,0.0003934765,0.00007753599,0.0002284848,0.001121329,0.001096046,0.04635011,0.911794],"study_design_scores_gemma":[0.00002957143,0.0001520919,0.002734893,0.01443427,0.0006761417,0.003988438,0.0001169452,0.0001204758,0.0005272013,0.00113336,0.9760582,0.0000284688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001485791,0.998943,0.00006637249,0.0002532272,0.0001899665,0.000003098069,0.00002623793,0.000007478722,0.0003621142],"genre_scores_gemma":[0.0007120639,0.9984961,0.0001589582,0.0001420749,0.0002165892,0.000004686106,0.00004853993,0.000001301004,0.0002196709],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003487446,"threshold_uncertainty_score":0.01166666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0470472189817733,"score_gpt":0.3263205790835084,"score_spread":0.2792733601017351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}