{"id":"W2154497902","doi":"10.1161/circgenetics.108.820795","title":"Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves","year":2009,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research","keywords":"Pathogenesis; Microarray; Gene; Microarray analysis techniques; Aortic valve; Population; Gene expression; Candidate gene; Biological pathway; Biology; Gene expression profiling; Genetics; Bioinformatics; Pathology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573821,0.000191291,0.000241271,0.0005342252,0.0002148287,0.0003378881,0.0001321837,0.0002256421,0.00068498],"category_scores_gemma":[0.0002292712,0.0000888478,0.0002464116,0.0003689183,0.0002828899,0.0001328399,0.000139993,0.0002416142,0.0001363938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631721,"about_ca_system_score_gemma":0.0001621467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003992032,"about_ca_topic_score_gemma":0.0006222895,"domain_scores_codex":[0.9998553,0.00001838106,0.00001035888,0.00005473938,0.00003650013,0.00002470787],"domain_scores_gemma":[0.9998935,0.00003847924,0.00001761948,0.000009337534,0.00002198052,0.00001909138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00037114,0.00004475118,0.01141633,0.0001287993,0.00001723102,0.00006881433,0.0001092252,0.0001051585,0.9840067,0.00003808313,0.00003286426,0.003660846],"study_design_scores_gemma":[0.00004664761,0.001138844,0.6168859,0.00002718814,0.0001414648,0.001420028,0.0004948893,0.002645151,0.3742675,0.00039111,0.00251543,0.00002574085],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961841,0.001220689,0.001897042,0.00002857048,0.00001089904,0.00002414734,0.0003328593,0.00001507902,0.0002867217],"genre_scores_gemma":[0.9891267,0.001209384,0.007484263,0.00007104708,0.00002225638,0.00007733106,0.00129024,0.000006083075,0.0007125964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00068498,"threshold_uncertainty_score":0.002291501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02985374188561265,"score_gpt":0.303116584872402,"score_spread":0.2732628429867893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}