{"id":"W2154515392","doi":"10.1016/s0828-282x(06)70238-0","title":"Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: The Heart Outcomes Prevention Evaluation (HOPE)-2 trial","year":2006,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Homocysteine; Vitamin B12; Placebo; Internal medicine; Population; Randomized controlled trial; Stroke (engine); B vitamins; Myocardial infarction; Risk factor; Hyperhomocysteinemia; Diabetes mellitus; Physical therapy; Surgery; Endocrinology; Environmental health; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0400009,0.006239671,0.007014376,0.001301853,0.002610788,0.003833979,0.003019225,0.005544774,0.01704863],"category_scores_gemma":[0.03864555,0.003857795,0.003941588,0.001405072,0.005435263,0.002635838,0.001357821,0.007195164,0.004814792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002094683,"about_ca_system_score_gemma":0.005147536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367614,"about_ca_topic_score_gemma":0.002015166,"domain_scores_codex":[0.9764497,0.01550651,0.001938975,0.003147009,0.001729988,0.001227793],"domain_scores_gemma":[0.9929354,0.00248355,0.001308549,0.001048404,0.0008100148,0.001414102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8556591,0.009219301,0.01682072,0.01176552,0.009622327,0.0009850679,0.0009696913,0.002961958,0.00380978,0.02433688,0.02697961,0.03687002],"study_design_scores_gemma":[0.8833477,0.03147236,0.01431104,0.001570782,0.008116945,0.0006867564,0.0002898062,0.004143151,0.001453294,0.01732517,0.03699455,0.0002883715],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1061042,0.01604331,0.03161999,0.01236538,0.00786014,0.8005711,0.01447428,0.0005689182,0.01039263],"genre_scores_gemma":[0.2129848,0.002365511,0.03264184,0.01224441,0.001794535,0.7285385,0.004783509,0.0000933592,0.004553634],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0400009,"threshold_uncertainty_score":0.2115475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318957288137454,"score_gpt":0.3035730797887533,"score_spread":0.2803835069073787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}