{"id":"W2154528654","doi":"10.1101/gad.1987211","title":"Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":498,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Universität Zürich; Canadian Institutes of Health Research; Oncosuisse; National Cancer Institute; Princess Margaret Hospital Foundation","keywords":"Biology; AMPK; Anaerobic glycolysis; Carnitine; Glycolysis; Cancer cell; Hypoxia (environmental); Beta oxidation; Cell biology; Cancer research; Warburg effect; Endocrinology; Internal medicine; Metabolism; Protein kinase A; Cancer; Kinase; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111323,0.0001841478,0.0002285766,0.00005478027,0.0000846205,0.000009185569,0.0001185789,0.00006785038,0.00006947741],"category_scores_gemma":[0.000009047281,0.0001731837,0.00005543834,0.00007312188,0.00009564275,0.000004614742,0.0000674196,0.00005033627,0.000004051894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004098669,"about_ca_system_score_gemma":0.0002235146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009930771,"about_ca_topic_score_gemma":0.0001920642,"domain_scores_codex":[0.9990155,0.00004652793,0.0002601462,0.0003012649,0.0001325558,0.0002440329],"domain_scores_gemma":[0.9994951,0.000007141424,0.0000689158,0.0001774051,0.0001374324,0.0001139467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006947964,0.0002562967,0.01376049,0.0001358787,0.000202692,0.00000322584,0.0009142312,0.000004052647,0.9791448,0.0009898193,0.0001547651,0.004364335],"study_design_scores_gemma":[0.0006168078,0.00004403369,0.08667702,0.00001093842,0.00005968584,0.000009516296,0.0003027463,5.741284e-7,0.8925371,0.00009381271,0.0194314,0.0002163215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987114,0.01027439,0.0006018648,0.00001717556,0.0004475246,0.0002169556,0.0001112061,0.0000103749,0.001206482],"genre_scores_gemma":[0.9939815,0.002651151,0.002490384,0.00006936823,0.0002545502,0.00005992829,0.0001936952,0.00002270142,0.0002766584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08660759,"threshold_uncertainty_score":0.7062228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577742310299635,"score_gpt":0.2219101830982195,"score_spread":0.2061327599952232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}