{"id":"W2154532141","doi":"10.1038/nature14125","title":"An epigenome-wide association study of total serum immunoglobulin E concentration","year":2015,"lang":"en","type":"review","venue":"Nature","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Jewish General Hospital; McGill University and Génome Québec Innovation Centre; University of Toronto; Ontario Institute for Cancer Research; Université du Québec à Chicoutimi","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Immunoglobulin E; Genome-wide association study; Biology; Immunology; Hay fever; Epigenetics; Epigenome; CpG site; DNA methylation; Single-nucleotide polymorphism; Genetic association; Genetics; Population; Eosinophil; Antibody; Allergy; Gene; Genotype; Asthma; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001165401,0.000766616,0.001799172,0.001450122,0.000172023,0.0007006269,0.0007184377,0.0008738847,0.001513751],"category_scores_gemma":[0.001849317,0.0002898172,0.001656123,0.002928332,0.000244216,0.0005762639,0.0008558558,0.0009105686,0.0002865786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115382,"about_ca_system_score_gemma":0.001008282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00279944,"about_ca_topic_score_gemma":0.005340527,"domain_scores_codex":[0.9995676,0.00009521071,0.0000847059,0.0001352435,0.00008526359,0.00003191447],"domain_scores_gemma":[0.9990243,0.0005839118,0.0001714706,0.0000343874,0.0001409831,0.00004497401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001161561,0.0001122313,0.06098115,0.04091336,0.01293925,0.0008218962,0.000176429,0.0004965845,0.003764925,0.001537222,0.01589142,0.861204],"study_design_scores_gemma":[0.0004030629,0.0005537248,0.4800357,0.01583031,0.05011793,0.005615116,0.0004907812,0.0007893671,0.002685363,0.006415223,0.4367904,0.0002730311],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003157349,0.9950401,0.0003042132,0.0005628684,0.0001907799,0.000007387921,0.0003304839,0.000007812172,0.0003989957],"genre_scores_gemma":[0.02459337,0.9718252,0.0009621877,0.0008204918,0.0004348313,0.00001978778,0.0008177678,0.000004744242,0.0005216248],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00279944,"threshold_uncertainty_score":0.006163299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993306671475464,"score_gpt":0.3526614181935191,"score_spread":0.3327283514787645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}