{"id":"W2154554591","doi":"10.1186/gb-2005-6-10-r85","title":"The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure","year":2005,"lang":"en","type":"article","venue":"Genome biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Canadian Institute for Advanced Research","funders":"Canadian Institutes of Health Research","keywords":"Extant taxon; Most recent common ancestor; Nuclear pore; Biology; Nucleoporin; Evolutionary biology; Phylogenetic tree; Sequence (biology); Phylogenetics; Gene; Genetics; Nucleus; Cell nucleus; Nuclear transport; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329774,0.0001211209,0.0001359648,0.00004035291,0.0001303556,0.00001042481,0.0002266708,0.0001550325,0.00005204618],"category_scores_gemma":[0.00001933449,0.00008838603,0.00004632596,0.00008609969,0.0001425278,0.000004708728,0.00009568677,0.0001094798,0.000005123924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003595167,"about_ca_system_score_gemma":0.00003976631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004787659,"about_ca_topic_score_gemma":0.0005564824,"domain_scores_codex":[0.9990798,0.00009736139,0.0002339196,0.0002821321,0.00005690406,0.0002499351],"domain_scores_gemma":[0.9994333,0.000005722977,0.0001156457,0.0003347955,0.00006449803,0.00004597219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001259333,0.00001770045,0.002941634,0.000003857236,0.0000168987,5.634673e-7,0.0000844444,0.0001835851,0.9905117,0.001855702,0.0001388122,0.004119201],"study_design_scores_gemma":[0.001436882,0.001562859,0.2080378,0.000007351768,0.00001857037,0.00005470444,0.0004349722,0.0006457133,0.01349012,0.0008742674,0.7730498,0.0003869614],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981067,0.0006071818,0.0001376815,0.0003012548,0.0001345754,0.0002329211,0.00004682724,0.00001120735,0.0004216933],"genre_scores_gemma":[0.9968601,0.0000165097,0.002057492,0.0002447459,0.0005521094,0.000004784641,0.0002105273,0.0000164641,0.000037248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9770216,"threshold_uncertainty_score":0.3604278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083020332527496,"score_gpt":0.2402580042561657,"score_spread":0.2294278009308908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}