{"id":"W2154620339","doi":"10.1161/01.res.0000192146.85173.4b","title":"Enhanced Store Overload–Induced Ca <sup>2+</sup> Release and Channel Sensitivity to Luminal Ca <sup>2+</sup> Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death","year":2005,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Sudden death; Mutation; Mutant; Biology; Cell biology; HEK 293 cells; Chemistry; Internal medicine; Genetics; Medicine; Cell culture; Gene; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195908,0.0002358123,0.0003561041,0.0003127571,0.0001575088,0.0002827896,0.0002383589,0.0003934334,0.001130365],"category_scores_gemma":[0.0001733045,0.0001078281,0.000365417,0.000237469,0.0002467612,0.0002115507,0.0002323591,0.000425705,0.0003136481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463378,"about_ca_system_score_gemma":0.000113799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004276838,"about_ca_topic_score_gemma":0.0004953938,"domain_scores_codex":[0.9997894,0.00002055322,0.00003161387,0.00004887364,0.00007817736,0.00003134635],"domain_scores_gemma":[0.9998102,0.00003717834,0.0000606895,0.00002844614,0.00002291216,0.00004063894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002658852,0.000007145191,0.0003057189,0.000008793102,0.000002690164,0.00007622867,0.0000126616,0.00001558134,0.9992817,0.00002816588,0.00001150182,0.0002232872],"study_design_scores_gemma":[0.0000227468,0.0002293364,0.05489082,0.000006105317,0.0000250072,0.003005809,0.0001037691,0.001808646,0.9382438,0.0001112216,0.00153797,0.00001478106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942873,0.0003512808,0.003804548,0.00006581922,0.00001469337,0.00002086999,0.000909083,0.00007536027,0.0004709878],"genre_scores_gemma":[0.9943511,0.0003125824,0.003064632,0.00006056242,0.000009085839,0.00004492332,0.0009909468,0.00004975163,0.001116198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130365,"threshold_uncertainty_score":0.003781497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03442123044678928,"score_gpt":0.3298201506239873,"score_spread":0.295398920177198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}