{"id":"W2154620339","doi":"10.1161/01.res.0000192146.85173.4b","title":"Enhanced Store Overload–Induced Ca 2+ Release and Channel Sensitivity to Luminal Ca 2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death","year":2005,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Sudden death; Mutation; Mutant; Biology; Cell biology; HEK 293 cells; Chemistry; Internal medicine; Genetics; Medicine; Cell culture; Gene; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008475906,0.0002383933,0.0005623326,0.0006041364,0.0004005628,0.00004009541,0.000056362,0.0002658516,0.00002326523],"category_scores_gemma":[0.00103743,0.0002493189,0.0001332009,0.0008216948,0.0001114143,0.0002202192,0.0001068116,0.000603065,0.0000431541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141866,"about_ca_system_score_gemma":0.0002079571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004739924,"about_ca_topic_score_gemma":0.00003932993,"domain_scores_codex":[0.9972406,0.0005655711,0.0003477809,0.0006119735,0.000682206,0.0005518617],"domain_scores_gemma":[0.997796,0.0005166099,0.000100823,0.0004319462,0.0007046034,0.0004500079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.002510164,0.0005672558,0.02040401,0.0006153955,0.0005400248,0.001061202,0.01789407,0.6702431,0.2721405,0.0001944455,0.001616739,0.01221307],"study_design_scores_gemma":[0.002875607,0.0008921084,0.7892467,0.0004798305,0.0002079816,0.000420117,0.002907513,0.1719168,0.03019536,0.0001644568,0.0001883391,0.0005051315],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957095,0.0001327768,0.0006015744,0.001759779,0.00002624809,0.001540442,0.00004412153,0.00004239312,0.0001431206],"genre_scores_gemma":[0.9985732,0.00002258979,0.0001085664,0.0002847612,0.0005656456,0.0001127103,0.0002227819,0.00003513955,0.00007461295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7688428,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03442123044678928,"score_gpt":0.3298201506239873,"score_spread":0.295398920177198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}