{"id":"W2154695733","doi":"10.1158/0008-5472.can-07-6778","title":"Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Efflux; Cell biology; Transport protein; Transporter; Transmembrane protein; Small interfering RNA; ATP-binding cassette transporter; Biology; Chemistry; Biochemistry; Cell; RNA; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003731798,0.0001171557,0.0003027759,0.0002486877,0.0001360036,0.00000341777,0.00007277699,0.0001182827,0.0002895058],"category_scores_gemma":[0.00005948561,0.00009278165,0.00005968796,0.0003187318,0.0003965121,0.0001177048,0.00002881025,0.0002036768,0.000001801065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008492635,"about_ca_system_score_gemma":0.000236169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535404,"about_ca_topic_score_gemma":0.0001055722,"domain_scores_codex":[0.9982373,0.00008762426,0.0002955106,0.0002889663,0.0008430019,0.0002475657],"domain_scores_gemma":[0.9989081,0.00005429693,0.0001120112,0.0003288643,0.0004632863,0.0001334266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002025787,0.0001169947,0.006618898,0.0009036816,0.00002362238,0.000008133541,0.0005452477,0.000001900172,0.9876453,0.0001306651,0.0003996774,0.001580136],"study_design_scores_gemma":[0.001082929,0.0001195901,0.2358427,0.001009378,0.00001357183,0.000001689993,0.0001257143,0.000008565738,0.7605356,0.0001333271,0.001053293,0.00007367888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994965,0.003486166,0.0001932254,0.0001057635,0.00004815082,0.000787917,0.00004114736,0.00002447251,0.0003481838],"genre_scores_gemma":[0.9928394,0.0004460912,0.0004464611,0.000007685166,0.00009873609,0.0001280433,0.00002029843,0.00002383248,0.005989477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2292238,"threshold_uncertainty_score":0.3783526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05914634292552565,"score_gpt":0.3288967494928366,"score_spread":0.269750406567311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}