{"id":"W2154718868","doi":"10.1128/aac.44.3.528-532.2000","title":"<i>pncA</i> Mutations as a Major Mechanism of Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> : Spread of a Monoresistant Strain in Quebec, Canada","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Potts Memorial Foundation","keywords":"Pyrazinamide; Mycobacterium tuberculosis; Biology; Mutation; Drug resistance; Microbiology; Genetics; Gene; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155229,0.0001898677,0.0006025837,0.000136959,0.00002993797,0.000008175118,0.0001094953,0.0001158136,0.0004829038],"category_scores_gemma":[0.00003701705,0.0001731981,0.00007867299,0.0003028767,0.0001344764,0.00006900999,0.00001663135,0.0001784641,0.000001982058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261126,"about_ca_system_score_gemma":0.0003941964,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6901704,"about_ca_topic_score_gemma":0.9246919,"domain_scores_codex":[0.998393,0.00009424237,0.0006132923,0.0003187202,0.000180412,0.0004003582],"domain_scores_gemma":[0.9994073,0.00007475835,0.0001051741,0.0002335031,0.00005561968,0.0001236279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007345709,0.001969162,0.1312818,0.001586072,0.0005182434,0.0005351214,0.003551333,0.00004232692,0.7873438,0.001630019,0.04890607,0.01529033],"study_design_scores_gemma":[0.01017318,0.0003283955,0.8664418,0.001265848,0.00007964527,0.00004501592,0.0004196799,0.0001535561,0.09350985,0.001193539,0.02585313,0.0005363341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862012,0.0001352542,0.000004866083,0.01152836,0.00002601957,0.0004172052,0.0001605739,0.000007541553,0.00151896],"genre_scores_gemma":[0.990312,0.002532213,0.0003065006,0.00536328,0.00002150883,0.00001455342,0.00006729084,0.00002365475,0.001358967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.73516,"threshold_uncertainty_score":0.7062813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007923946260548946,"score_gpt":0.2557661901280946,"score_spread":0.2478422438675456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}