{"id":"W2154718868","doi":"10.1128/aac.44.3.528-532.2000","title":"<i>pncA</i> Mutations as a Major Mechanism of Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> : Spread of a Monoresistant Strain in Quebec, Canada","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Potts Memorial Foundation","keywords":"Pyrazinamide; Mycobacterium tuberculosis; Biology; Mutation; Drug resistance; Microbiology; Genetics; Gene; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716848,0.0003280963,0.0003425496,0.0009132352,0.001884662,0.0008764092,0.0006974646,0.0005120121,0.001658862],"category_scores_gemma":[0.0007193181,0.000199538,0.0002743906,0.001039862,0.0004815515,0.0001852475,0.0002759818,0.0005163355,0.0001605167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009714346,"about_ca_system_score_gemma":0.006817518,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9735488,"about_ca_topic_score_gemma":0.9776118,"domain_scores_codex":[0.9996033,0.00002958673,0.00002225629,0.00009501075,0.0001276633,0.0001222255],"domain_scores_gemma":[0.9991956,0.00005517344,0.0001102552,0.00002356041,0.0004367787,0.0001785802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007653761,0.0002181344,0.8890755,0.0001944287,0.000156657,0.003082228,0.002251542,0.001058203,0.06615555,0.0005192213,0.003286031,0.03323711],"study_design_scores_gemma":[0.00003530592,0.000142205,0.9852208,0.0000612903,0.00007158799,0.001261277,0.001247241,0.00136892,0.005061366,0.00003320735,0.005452135,0.00004448129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941398,0.001232772,0.0003247637,0.0003204886,0.00001793602,0.00007562417,0.0007774549,0.0000219347,0.003089221],"genre_scores_gemma":[0.9970971,0.0004401242,0.0004225902,0.0001649585,0.000006006071,0.00001027822,0.0005370178,0.000008187527,0.001313631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02645117,"threshold_uncertainty_score":0.07048285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007923946260548946,"score_gpt":0.2557661901280946,"score_spread":0.2478422438675456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}