{"id":"W2154726349","doi":"10.2337/db13-0340","title":"Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"mitochondrial fusion; PI3K/AKT/mTOR pathway; Insulin; Protein kinase B; MFN2; Cell biology; Mitochondrion; Biology; Myocyte; Insulin receptor; Signal transduction; Internal medicine; Endocrinology; Insulin resistance; Medicine; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526042,0.0001769214,0.0001823868,0.00006433891,0.0001219853,0.00005564907,0.0001097363,0.0002063138,0.0001306403],"category_scores_gemma":[0.0001382544,0.0001311062,0.00007492468,0.0001100234,0.00008779624,0.00001157257,0.00009745755,0.0001387025,0.00005426041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009288337,"about_ca_system_score_gemma":0.00002540602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006297611,"about_ca_topic_score_gemma":0.00001853408,"domain_scores_codex":[0.9988641,0.0001712191,0.0002286399,0.0003611324,0.0001009011,0.0002740773],"domain_scores_gemma":[0.9994566,0.00007699124,0.00006770845,0.0002558598,0.00007424834,0.0000685899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005669857,0.00002487152,0.0122966,0.00001072914,0.00002408318,7.905248e-7,0.00006322255,0.0001377696,0.9776407,0.00002528032,0.0007909166,0.008928288],"study_design_scores_gemma":[0.001741213,0.000653219,0.01489845,0.00003000303,0.00003723505,0.000005473535,0.0001687479,0.00104808,0.9483472,0.001055332,0.03161233,0.0004027414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957079,0.001906487,0.0005708817,0.0001752112,0.0009829839,0.0003806213,0.000007743445,0.0000206215,0.0002475199],"genre_scores_gemma":[0.9979181,0.00005577822,0.0002850082,0.0004661232,0.0008440265,0.00009318088,0.00009892302,0.00002050327,0.0002183507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03082141,"threshold_uncertainty_score":0.5346357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007589359293392275,"score_gpt":0.203438888557102,"score_spread":0.1958495292637098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}