{"id":"W2154769298","doi":"10.1124/dmd.105.004424","title":"NEUROPHARMACOKINETICS OF A NEW α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) MODULATOR, S18986 [(S)-2,3-DIHYDRO-[3,4]CYCLOPENTANO-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE], IN THE RAT","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Pharmacokinetics; Chemistry; Microdialysis; Blood–brain barrier; AMPA receptor; Extracellular fluid; Stereochemistry; Pharmacology; Glutamate receptor; Receptor; Biochemistry; Internal medicine; Extracellular; Medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004162745,0.0003640028,0.0006460313,0.0002602189,0.0001193692,0.00004292672,0.0002370331,0.0001265822,0.0000975261],"category_scores_gemma":[0.00001977424,0.0002596032,0.0001938747,0.0005992556,0.00009940426,0.0003232394,0.00003831426,0.0003770267,0.0000204509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003321783,"about_ca_system_score_gemma":0.0001064473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001027612,"about_ca_topic_score_gemma":0.0001412068,"domain_scores_codex":[0.9976792,0.0001378712,0.0006563662,0.000480175,0.0006009717,0.0004453565],"domain_scores_gemma":[0.9989749,0.00004250053,0.0001919254,0.0004718255,0.00007325454,0.0002455801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001146965,0.001197163,0.00400877,0.0004286524,0.0001271738,0.0001295523,0.007560842,0.0007461422,0.9466174,0.01000231,0.001361862,0.02667317],"study_design_scores_gemma":[0.01224092,0.00020949,0.305479,0.0004176947,0.00138357,0.0001969236,0.001144643,0.004200328,0.6273261,0.00178008,0.04472082,0.0009004924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841172,0.009802132,0.0008414105,0.002697642,0.0003925665,0.001026049,0.00003226725,0.00005703047,0.001033765],"genre_scores_gemma":[0.9941804,0.001795542,0.001017239,0.001254731,0.0005128612,0.0000453792,0.0001179248,0.00004613039,0.001029836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3192913,"threshold_uncertainty_score":0.9999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008391943861205425,"score_gpt":0.2449075106534943,"score_spread":0.2365155667922889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}