{"id":"W2154769298","doi":"10.1124/dmd.105.004424","title":"NEUROPHARMACOKINETICS OF A NEW α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) MODULATOR, S18986 [(S)-2,3-DIHYDRO-[3,4]CYCLOPENTANO-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE], IN THE RAT","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Pharmacokinetics; Chemistry; Microdialysis; Blood–brain barrier; AMPA receptor; Extracellular fluid; Stereochemistry; Pharmacology; Glutamate receptor; Receptor; Biochemistry; Internal medicine; Extracellular; Medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208676,0.0007895868,0.0005021306,0.0006490595,0.0002115636,0.0003436286,0.0002718771,0.0004192934,0.001053854],"category_scores_gemma":[0.0004310854,0.0003724344,0.0003585207,0.000339001,0.0005545626,0.0006361961,0.0001479071,0.0009436318,0.0003394589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004439146,"about_ca_system_score_gemma":0.0004874346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002497283,"about_ca_topic_score_gemma":0.003363791,"domain_scores_codex":[0.9998385,0.00004210707,0.0000145977,0.00002922856,0.00003332526,0.00004229094],"domain_scores_gemma":[0.999483,0.00006855542,0.0001731346,0.00007576823,0.0000523997,0.0001470723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.07086431,0.002975749,0.01045229,0.0001470544,0.0002181308,0.000442901,0.0001701898,0.0009680953,0.8760957,0.0003526529,0.0004018794,0.03691107],"study_design_scores_gemma":[0.001643213,0.08406938,0.06310391,0.00003473706,0.0008334099,0.0008837567,0.0003356753,0.003056589,0.8429945,0.0003650226,0.002591871,0.00008800397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998176,0.0007575504,0.0003343025,0.00006613811,0.00001929503,0.00001434995,0.000307519,0.00003780653,0.0002870657],"genre_scores_gemma":[0.9944589,0.002435882,0.0006115095,0.00007150041,0.0000355233,0.00004039931,0.0005631693,0.00001982929,0.001763146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002497283,"threshold_uncertainty_score":0.004965425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008391943861205425,"score_gpt":0.2449075106534943,"score_spread":0.2365155667922889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}