{"id":"W2154769581","doi":"10.1093/protein/15.5.413","title":"Enhanced proliferative effects of a baculovirus-produced fusion protein of insulin-like growth factor and α1-proteinase inhibitor and improved anti-elastase activity of the inhibitor with glutamate at position 351","year":2002,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Fusion protein; Proteinase inhibitor; Pancreatic elastase; Proteolysis; Elastase; Biochemistry; Growth factor; Chemistry; Oligopeptide; Molecular biology; Biology; Enzyme; Peptide; Recombinant DNA; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000089823,0.0002059564,0.0002216372,0.00006593919,0.0001047536,0.00001442375,0.00003939599,0.0001287629,0.000002096236],"category_scores_gemma":[0.0001180469,0.0001521719,0.00004050754,0.0001593579,0.00008073166,0.00002515007,0.00007313317,0.0001022669,8.136051e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001949224,"about_ca_system_score_gemma":0.00002320095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003264395,"about_ca_topic_score_gemma":0.000004208562,"domain_scores_codex":[0.9990811,0.0001221154,0.0001963391,0.0003229726,0.000125536,0.0001518825],"domain_scores_gemma":[0.9994535,0.00001656123,0.0002038084,0.0001191551,0.0001387349,0.00006823814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007008688,0.000140291,0.0001494405,0.0007524695,0.00004828182,4.445563e-7,0.0001473164,0.0001207784,0.9971092,0.000008804059,0.0000054754,0.0008166583],"study_design_scores_gemma":[0.001238309,0.00222527,0.001841784,0.0003250183,0.00002731893,0.000009230341,0.00000387402,0.003165347,0.9909778,0.00001226441,0.000004673244,0.0001690976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799531,0.0005323873,0.01740071,0.00001943641,0.0000375479,0.002024672,0.00001465112,0.00001601998,0.00000143878],"genre_scores_gemma":[0.9982374,0.0000863485,0.001342099,0.00000508751,0.00004867938,0.0002261885,0.000003215795,0.00002249279,0.00002850232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828425,"threshold_uncertainty_score":0.6205389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004300443749999262,"score_gpt":0.1823949154207139,"score_spread":0.1780944716707146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}