{"id":"W2154769581","doi":"10.1093/protein/15.5.413","title":"Enhanced proliferative effects of a baculovirus-produced fusion protein of insulin-like growth factor and α1-proteinase inhibitor and improved anti-elastase activity of the inhibitor with glutamate at position 351","year":2002,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Fusion protein; Proteinase inhibitor; Pancreatic elastase; Proteolysis; Elastase; Biochemistry; Growth factor; Chemistry; Oligopeptide; Molecular biology; Biology; Enzyme; Peptide; Recombinant DNA; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101564,0.0003546246,0.0001684647,0.0001585871,0.00008508233,0.0002467134,0.0001611226,0.0001982003,0.0005064013],"category_scores_gemma":[0.00005892837,0.0001038498,0.0001609508,0.0001380491,0.0001482303,0.000114968,0.000141055,0.0003530505,0.000167929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856038,"about_ca_system_score_gemma":0.0001319638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006358736,"about_ca_topic_score_gemma":0.0006587866,"domain_scores_codex":[0.9999033,0.00001482727,0.000009713317,0.00002295095,0.00003027856,0.00001896394],"domain_scores_gemma":[0.9999528,0.00001078585,0.0000151339,0.000004439707,0.000004576857,0.0000123609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002987065,0.000008366615,0.00002657865,0.000009620075,0.000001565058,0.00001467046,0.000003750903,0.00002636855,0.9995444,0.00004035929,0.000005453229,0.0002889892],"study_design_scores_gemma":[0.00000647409,0.0001411725,0.001017201,0.000001863436,0.000009602482,0.0001012189,0.000005394308,0.0004188262,0.9968178,0.000008501821,0.001470026,0.000001969931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994404,0.001503994,0.002102938,0.00003631241,0.00002411318,0.00002167895,0.0001968351,0.00004821084,0.001662069],"genre_scores_gemma":[0.9918057,0.0007705835,0.003951271,0.00003406413,0.000009260611,0.00001882708,0.0006263486,0.00002128327,0.002762735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006358736,"threshold_uncertainty_score":0.002797723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004300443749999262,"score_gpt":0.1823949154207139,"score_spread":0.1780944716707146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}