{"id":"W2154788828","doi":"10.1128/jvi.01552-06","title":"Distinct Transcriptional Profiles in Ex Vivo CD4<sup>+</sup>and CD8<sup>+</sup>T Cells Are Established Early in Human Immunodeficiency Virus Type 1 Infection and Are Characterized by a Chronic Interferon Response as Well as Extensive Transcriptional Changes in CD8<sup>+</sup>T Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Genome Canada","keywords":"Biology; CD8; Immunology; Virology; Ex vivo; Interferon; Cytotoxic T cell; Chronic infection; Virus; T cell; CXCL10; CXCR3; Interferon gamma; Chemokine; Cytokine; Immune system; In vivo; Chemokine receptor; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082339,0.0001569692,0.0002082261,0.000232213,0.0001195857,0.0003588221,0.00007233562,0.0001953045,0.001536433],"category_scores_gemma":[0.0001414804,0.0001050855,0.0002131945,0.0002303382,0.0001894569,0.0001508925,0.000142432,0.0003705769,0.0004044215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004595,"about_ca_system_score_gemma":0.00006999527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002705888,"about_ca_topic_score_gemma":0.0002890547,"domain_scores_codex":[0.9998701,0.0000188912,0.000009775265,0.00004619647,0.00002738956,0.00002764203],"domain_scores_gemma":[0.9998995,0.00002480726,0.00001970147,0.00001475124,0.00002040225,0.00002090621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000305165,0.00002417439,0.001954601,0.00002648391,0.000005185088,0.0000355332,0.00005500955,0.00004046279,0.996238,0.00001765837,0.00002816852,0.001269369],"study_design_scores_gemma":[0.00006442054,0.001321681,0.1779054,0.00002642442,0.00008200825,0.0009675216,0.0003978852,0.002038718,0.8136953,0.0001902689,0.003290295,0.00002014294],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971205,0.0004504552,0.001066419,0.00003333716,0.0000105647,0.00001026127,0.0008734645,0.00001652907,0.0004185159],"genre_scores_gemma":[0.9920591,0.0004655235,0.002017738,0.00009394417,0.00002769616,0.00006861615,0.002983438,0.00001654034,0.002267343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536433,"threshold_uncertainty_score":0.005139887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229136574006276,"score_gpt":0.2578384823417779,"score_spread":0.2455471166017151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}