{"id":"W2154788828","doi":"10.1128/jvi.01552-06","title":"Distinct Transcriptional Profiles in Ex Vivo CD4<sup>+</sup>and CD8<sup>+</sup>T Cells Are Established Early in Human Immunodeficiency Virus Type 1 Infection and Are Characterized by a Chronic Interferon Response as Well as Extensive Transcriptional Changes in CD8<sup>+</sup>T Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Genome Canada","keywords":"Biology; CD8; Immunology; Virology; Ex vivo; Interferon; Cytotoxic T cell; Chronic infection; Virus; T cell; CXCL10; CXCR3; Interferon gamma; Chemokine; Cytokine; Immune system; In vivo; Chemokine receptor; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00206919,0.0006115542,0.001177052,0.001613972,0.0002540804,0.00008196335,0.0003357429,0.0007925596,0.001687447],"category_scores_gemma":[0.0001743085,0.0005520983,0.0001955582,0.0005157024,0.0007378857,0.0005069357,0.00009436111,0.001808439,0.0002218636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006454753,"about_ca_system_score_gemma":0.0003358136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019581,"about_ca_topic_score_gemma":0.001274676,"domain_scores_codex":[0.9947907,0.00168374,0.00131443,0.0007624589,0.0002623413,0.001186336],"domain_scores_gemma":[0.998053,0.0006314045,0.0005615246,0.0002922635,0.0002831454,0.0001787344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02578118,0.001432312,0.01975662,0.0001050212,0.0002049966,0.0007505552,0.0038037,0.0002459792,0.9466664,0.00002947902,0.0002779859,0.0009457856],"study_design_scores_gemma":[0.03467794,0.02355888,0.7341592,0.00102202,0.0002616875,0.002680127,0.00399703,0.0003346397,0.1614081,0.0003894322,0.03611614,0.001394792],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897804,0.007747994,0.00006051835,0.0008206555,0.0002106351,0.000943664,0.0003223985,0.00002602552,0.00008769044],"genre_scores_gemma":[0.9963436,0.002160012,0.00002869483,0.0002383857,0.0001156661,0.00006945175,0.0001647325,0.00005504796,0.0008243704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7852583,"threshold_uncertainty_score":0.999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229136574006276,"score_gpt":0.2578384823417779,"score_spread":0.2455471166017151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}