{"id":"W2154796235","doi":"10.1158/1078-0432.ccr-07-0342","title":"Fas Ligand Delivery by a Prostate-Restricted Replicative Adenovirus Enhances Safety and Antitumor Efficacy","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Fas ligand; Prostate cancer; Bystander effect; Cancer research; Apoptosis; Prostate; Oncolytic virus; Systemic administration; In vivo; Biology; Antigen; Gene delivery; Genetic enhancement; Immune system; Cancer; Immunology; Medicine; Internal medicine; Programmed cell death; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292356,0.0004134678,0.0003166222,0.0003298837,0.00008577019,0.0003695618,0.0002044558,0.0002600062,0.0008239446],"category_scores_gemma":[0.0001812222,0.00009203522,0.0002569077,0.0002025962,0.0002405713,0.0003039,0.0001401995,0.0004801466,0.0002223159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003974784,"about_ca_system_score_gemma":0.0003224925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064452,"about_ca_topic_score_gemma":0.0003149258,"domain_scores_codex":[0.9997728,0.00004176991,0.0000239131,0.00004340485,0.00007679981,0.00004125054],"domain_scores_gemma":[0.9997905,0.0000398735,0.00007270349,0.0000313439,0.00003533432,0.00003028614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001847773,0.00007351636,0.000346277,0.00007516477,0.000009736599,0.00003697068,0.00001599372,0.0001871644,0.9920456,0.0001521566,0.00002922073,0.006843482],"study_design_scores_gemma":[0.00004226158,0.001496781,0.001469365,0.000007020561,0.00003884971,0.000343537,0.00001120817,0.001022199,0.9934065,0.00003954226,0.002118018,0.000004658238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894794,0.003988746,0.004966821,0.0001020906,0.00003169594,0.00005713585,0.00009442937,0.000182827,0.00109682],"genre_scores_gemma":[0.9945681,0.0008594751,0.003492423,0.00002311598,0.00001375264,0.00001433133,0.0001151788,0.0000144385,0.0008991499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008239446,"threshold_uncertainty_score":0.002883911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0613555043708848,"score_gpt":0.4433051042977801,"score_spread":0.3819495999268953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}