{"id":"W2154812064","doi":"10.1158/1078-0432.ccr-06-1653","title":"A Phase Ib and Pharmacokinetic Trial of Patupilone Combined with Carboplatin in Patients with Advanced Cancer","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Tolerability; Nausea; Pharmacokinetics; Vomiting; Adverse effect; Phases of clinical research; Area under the curve; Neutropenia; Internal medicine; Urology; Chemotherapy; Oncology; Gastroenterology; Pharmacology; Surgery; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274169,0.0001735625,0.0006541106,0.0002350502,0.00004844755,0.000006722446,0.00009545792,0.000107651,0.0003935166],"category_scores_gemma":[0.00009700919,0.000118187,0.00004865431,0.0006873721,0.0005851569,0.00005799932,0.00005566335,0.0007439878,0.000001601948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024955,"about_ca_system_score_gemma":0.0005777428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009284607,"about_ca_topic_score_gemma":0.001771712,"domain_scores_codex":[0.9975334,0.0001949366,0.0006132409,0.0004554225,0.0006712755,0.0005316958],"domain_scores_gemma":[0.9980976,0.0007758858,0.0001434868,0.0002218339,0.0004318038,0.0003293966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.566771,0.005213922,0.3352522,0.0001054434,0.0001748159,0.0000668491,0.00012448,0.000005413974,0.0005600104,0.000005227066,0.0002706108,0.09144998],"study_design_scores_gemma":[0.6025347,0.05751822,0.3351539,0.000315405,0.0001938374,9.911564e-7,0.00004075472,0.0000484003,0.002510103,0.00001305288,0.001514181,0.0001564094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950335,0.000962738,0.00000341136,0.0007128049,0.0002079562,0.002484994,0.00004237149,0.00001479737,0.0005374466],"genre_scores_gemma":[0.9975638,0.001201961,0.0001048526,0.0001836899,0.0002487829,0.0003354651,0.00002434264,0.00003172649,0.0003053227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09129357,"threshold_uncertainty_score":0.4819524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1423346884194122,"score_gpt":0.5699323937793035,"score_spread":0.4275977053598913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}